Volume 27, Issue 4 (Published 8 October 2013)                   Med J Islam Repub Iran 2013 | Back to browse issues page

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Maradni A, Khoshnevisan A, Mousavi S H, Emamirazavi S H, Noruzijavidan A. Role of matrix metalloproteinases (MMPs) and MMP inhibitors on intracranial aneurysms: a review article. Med J Islam Repub Iran. 2013; 27 (4) :249-254
URL: http://mjiri.iums.ac.ir/article-1-1963-en.html
Assistant Professor Department of Neurosurgery, Brain and spinal injury repair research center, Tehran University of medical sciences, Tehran, Iran. , akhoshnevisan@tums.ac.ir
Abstract:   (2525 Views)

Cerebrovascular disease is one of the leading causes of death in the world, and about one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms (CA). Hence it is important to find a way to reduce aneurysm formation and its subsequent morbidity and mortality. Proteolytic activity capable of lysing gelatin has been shown to be increased in aneurysm tissue and expression of plasmin, membrane-type matrix metalloproteinase- 1(MT1-MMP), and matrix metalloproteinase-2 (MMP-2) in aneurysmal wall is more than what we observe in normal cerebral arteries. MMP inhibitors such as doxycycline and statins may prohibit aneurysm formation and growth. MMPs are important in tissue remodeling associated with various physiological and pathological processes such as morphogenesis, angiogenesis, apoptosis and tissue repair. In this article we review the role of MMPs and MMP inhibitors in formation of aneurysm.

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Type of Study: Review Article | Subject: Neurosurgery

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