Volume 31, Issue 1 (1-2017)                   Med J Islam Repub Iran 2017 | Back to browse issues page

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Soleimani Asl S, Hesam Shariati M B, Medizadeh M, Ahmadpanah M, Sohrabi M. The effect of 3,4- methylenedioxymethamphetamine on expression of neurotrophic factors in hippocampus of male rats . Med J Islam Repub Iran. 2017; 31 (1) :344-348
URL: http://mjiri.iums.ac.ir/article-1-4121-en.html
Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. , sohrabi3@yahoo.com
Abstract:   (1672 Views)

Background: 3,4- methylenedioxymethamphetamine (MDMA) is a chemical derivative of amphetamine that can induce learning and memory impairment. Due to  the effect of neurotrophins  on memory and learning, the impact of MDMA was evaluated  on the brain - derived neurotrophic factor (BDNF), neurotrophin- 4 (NT-4), and tropomyosin- related kinase B (Trk- β) expression in the hippocampus.
   Methods: In this study, 20 adult male Wistar rats (200-250 g) received saline (1 mL) or 10 mg/kg of MDMA intraperitoneally as single or multiple injection for 2 consecutive days per week for 2 months. Expression of BDNF, Trk-β, and NT4 were assessed using Western blotting and RT PCR methods. 
   Results: Our results revealed that the expression of BDNF, Trk- β, and NT4 proteins and genes significantly decreased in MDMA groups compared to the sham group (p<0.05). Furthermore, the acute group showed the lowest expression of these proteins.
   Conclusion: The results of the present study suggest that ecstasy administration may downregulate the expression of BDNF, Trk- β, and NT-4 in hippocampus, which is more extensive in case of acute treatment. It seems that in the chronic group, hippocampus was able to compensate the ecstasy- induced neurotoxicity. 

Keywords: Ecstasy, BDNF, Trk- β, NT4
Full-Text [PDF 882 kb]   (379 Downloads)    
Type of Study: Original Research | Subject: Anatomical Sciences

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