Volume 32, Issue 1 (2-2018)                   Med J Islam Repub Iran 2018 | Back to browse issues page


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Heydari I, Honardoost M, Moradi S, Golgiri F, Dehnad H, Moradi S et al . Changes in the size of the thyroid in patients with benign non-toxic multinodular goiter after radioactive iodine therapy . Med J Islam Repub Iran. 2018; 32 (1) :769-772
URL: http://mjiri.iums.ac.ir/article-1-4647-en.html
Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism ,Iran University of Medical Sciences Tehran, Iran , Aziaee1963@yahoo.com
Abstract:   (851 Views)
Background: Multinodular goiter (MNG) is regarded as one of the most common causes of hyperthyroidism, particularly in areas of mild-to-moderate iodine deficiency. The present study aims to explore the effects of the radioactive iodine (RAI) therapy on benign non-toxic MNG and evaluate its side effects.
    Methods: Patients with benign non-toxic MNG entered the study. Ultrasonography was applied to calculate the percentage of the decrease in the size of the thyroid before and six months minimum after the treatment. Chi-square, Mann-Whiteny-U and T-test were done using SPSS v.18.0 (p<0.05). 
    Results: The volumes of the thyroid lobes and nodules decreased significantly due to RAI therapy (p<0.001). The total volume of the thyroid, volume of the right nodule, and volume of the left nodule decreased by 77.8%, 40.7%, and 34.6% respectively.
   Conclusion: According to the results of the current study, RAI therapy is an effective treatment method although it has short-term side effects. This treatment option is recommended for patients with benign non-toxic MNG, notably those who cannot be a candidate for surgery. This treatment affects the size of the thyroid and its nodules significantly and decreases almost all of the complications.
 
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