Volume 26, Issue 2 (5-2012)                   Med J Islam Repub Iran 2012 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Izadi F, Hamkar R, Ghanbari H, Abdolmotallebi F, Jahandideh H. The role of Human papilloma virus (HPV) genotyping in recurrent respiratory papillomatosis in Rasoul Akram Hospital. Med J Islam Repub Iran. 2012; 26 (2) :90-93
URL: http://mjiri.iums.ac.ir/article-1-503-en.html
Department of Otolaryngology, ENT.HNSresearch center, Tehran University of Medical Sciences. Rasoul Akram Hospital/Niayesh St. Sattarkhan Avenue, Tehran, Iran. , ghanbari_md@tums.ac.ir
Abstract:   (3985 Views)
 Background: The most common laryngeal mass in children is recurrent respiratory papillomatosis (RRP).  Studies have attempted to correlate viral typing and its aggressiveness.


Method: 29 patients with histologically confirmed RRP enrolled in adjuvant therapies. Patients underwent several surgical interventions.

 Results: HPV genotyping demonstrated 45% HPV-6 and 55% HPV-11. The mean age at the first surgical intervention was 52.39 months (SD=102.28) (range from 4 months to 426 months). The mean number of surgical intervention was 10.39 (SD=7.76) (range from 2 to 30). The mean time of surgical intervals was 4.63 months (SD=4.02) (range from 2 to 24 months). In fourteen patients (48%) tracheotomy was done. All patients who had tracheotomy received alpha-interferon. One of our cases was a male who had pulmonary extension with HPV-6.


Conclusion: A review of patients with RRP was regarding to HPV genotyping and need for adjuvant therapy and tracheostomy. Mean number of surgical procedure was 10/40 and nearly fourteen patients (48%) need to tracheotomy. The clinical differences between HPV6 and HPV11 disease may not be accurately predictable. Patients with less age and with HPV-11 seemed to have more severe problems, but these differences were not statistically significant which needs much more investigations for reasonable starting point of evaluation for these differences.

Full-Text [PDF 168 kb]   (1163 Downloads)    
Type of Study: Original Research | Subject: Otorhinolaryngology

Add your comments about this article : Your username or Email:

Send email to the article author