Volume 34, Issue 1 (2-2020)                   Med J Islam Repub Iran 2020 | Back to browse issues page

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Pashazadeh M. The role of tumor-isolated exosomes on suppression of immune reactions and cancer progression: A systematic review. Med J Islam Repub Iran. 2020; 34 (1) :639-645
URL: http://mjiri.iums.ac.ir/article-1-6199-en.html
Immunology Division, Department of Microbiology, Health Science Institute, Bursa Uludag University & Department of Immunology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey , mehrdad_pashazadeh@yahoo.com
Abstract:   (661 Views)
Background: Exosomes are extracellular cells (EVs) emancipated by various cell types and are involved in cell-to-cell transmission. In cancer diseases, exosomes emerge as local and systemic cells to cell mediators of oncogenic information and play a significant role in the advancement of cancer through the horizontal transfer of various molecules, such as proteins and miRNAs.
   Methods: In this study, 66 articles from PubMed, MEDLINE, Science Direct, Cochrane, EMBASE, and Scopus were used as English sources.
   Results: The biological distribution of cancer cell-derived exosomes in tumor tissue is an important factor in detecting their role in tumor increase; on the other hand, a limited number of studies have examined the biodistribution of exosomes in tumor tissues. While exosomes function as cancer biomarkers and support cancer treatment, we have a long way to improve the antitumor treatment of exosomes and develop exosome-based cancer diagnostic and therapeutic strategies. 
   Conclusion: This review describes the science and significance of cancer pathogenesis and exosomes relative to cancer treatment resistance.
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Type of Study: Systematic Review | Subject: Immunology

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