Volume 12, Issue 4 (2-1999)                   Med J Islam Repub Iran 1999 | Back to browse issues page


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REZAYAT M, HOSSEINI H, AKHONDIAN J, VAHDATI N, ZARRINDAST M. INFLUENCE OF CCK RECEPTOR AGONIST AND ANTAGONISTS ON TOLERANCE INDUCED TO ANTIPENTYLENETETRAZOL ACTIVITY OF DIAZEPAM . Med J Islam Repub Iran. 1999; 12 (4) :365-369
URL: http://mjiri.iums.ac.ir/article-1-989-en.html

From the Department of Pharmacology, Tehran and Mashhad Universities of Medical Sciences, I.R. Iran.
Abstract:   (1754 Views)
In the present study, the effects of caerulein and CCK receptor antagonist< on tolerance to the anti-pentylenetetrazol activity of diazepam has been studied. Different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48 h after the last dose of diazepam, a test dose of diazepam was tested for antipentylenetetrazol activity. When animals were treated with caerulein or the CCK receptor antagonists MK -329 and L-365,260, only L-365,260 reversed the tolerance to diazepam. It may be concluded that CCK-B receptor mechanisms may interact with tolerance induced by diazepam.
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