Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Mon, Mar 17, 2025
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Volume 33, Issue 1 (2-2019)
Med J Islam Repub Iran 2019 |
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Soleimani Asl S, Bergen H, Ashtari N, Amiri S, Łos M J, Mehdizadeh M. Pelargonidin exhibits restoring effects against amyloid β-induced deficits in the hippocampus of male rats. Med J Islam Repub Iran 2019; 33 (1) :822-827
URL: http://mjiri.iums.ac.ir/article-1-5647-en.html
URL: http://mjiri.iums.ac.ir/article-1-5647-en.html
Sara Soleimani Asl 
, Hugo Bergen , Niloufar Ashtari , Shayan Amiri , Marek J. Łos , Mehdi Mehdizadeh
, Hugo Bergen , Niloufar Ashtari , Shayan Amiri , Marek J. Łos , Mehdi Mehdizadeh
Cellular and Molecular Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran , MEHDIZADEH.M@IUMS.AC.IR
Abstract: (2814 Views)
Background: Alzheimer's disease (AD) is characterized by amyloid-beta plaques, neuronal loss, and cognitive dysfunction. Oxidative stress plays a key role in the pathophysiology of AD, and it has been suggested that antioxidants may slow the progress of the disease. In this study, the possible protective effects of pelargonidin (a natural flavonoid) against amyloid β (Aβ)-induced behavioral deficits was investigated in rats.
Methods: Adult Wistar male rats were treated with intrahippocampal injections of the Aβ (aa 25-35) and intraperitoneal injection of pelargonidin. Learning and spatial memory were tested using the Morris water maze (MWM) task. The antioxidant activity was evaluated using the ferric reducing/antioxidant power assay (FRAP assay). Data were analyzed using SPSS 20, and value of p≤0.05 was considered significant.
Results: The results of this study showed that Aβ significantly increased escape latency and the distance traveled in the MWM, and pelargonidin attenuated these behavioral changes. Aβ induced a significant decrease in the total thiol content of hippocampus, and pelargonidin restored the hippocampal antioxidant capacity.
Conclusion: The results of this study suggest that pelargonidin can improve Aβ-induced behavioral changes in rats.
Methods: Adult Wistar male rats were treated with intrahippocampal injections of the Aβ (aa 25-35) and intraperitoneal injection of pelargonidin. Learning and spatial memory were tested using the Morris water maze (MWM) task. The antioxidant activity was evaluated using the ferric reducing/antioxidant power assay (FRAP assay). Data were analyzed using SPSS 20, and value of p≤0.05 was considered significant.
Results: The results of this study showed that Aβ significantly increased escape latency and the distance traveled in the MWM, and pelargonidin attenuated these behavioral changes. Aβ induced a significant decrease in the total thiol content of hippocampus, and pelargonidin restored the hippocampal antioxidant capacity.
Conclusion: The results of this study suggest that pelargonidin can improve Aβ-induced behavioral changes in rats.
Keywords: Alzheimer’s disease, Amyloid β-peptide, Pelargonidin, Memory impairment, Hippocampus, Oxidative stress
Type of Study: Original Research |
Subject:
Physiology
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