Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Thu, Apr 3, 2025
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Volume 19, Issue 4 (2-2006)
Med J Islam Repub Iran 2006 |
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Mansouri Torghabeh H. Letter to the Editor. Med J Islam Repub Iran 2006; 19 (4) :367-367
URL: http://mjiri.iums.ac.ir/article-1-565-en.html
URL: http://mjiri.iums.ac.ir/article-1-565-en.html
Department of Experimental Hematology and Blood Banking, Tarbiat , Mansouritorghabe@mums.ac.ir
Abstract: (4282 Views)
I enjoyed the article by 1. Eivazi Ziai, et al. concerning
"Use of myeloperoxidase index as a suitable tool to
monitor response to therapy in patients with megaloblastic
anemia" that was published in the last issue of
the Medical Journal ofIslamic Republic of Iran. I I would
like to make some points regarding this study.
A. The authors mentioned that in primary evaluation
of 50 anemic patients who had referred to their center,
the peripheral blood smear and bone marrow aspirations
had shown typical megaloblastic features. As all of the
patients had been prescribed Vitamin BI2 and folate, it
shows that the study has been on the basis of megaloblastic
anemia due to vitamin BI2 and folate deficiency.
The patients have entered the study without assessing
excluding criteria for megaloblastic anemia, because there
are several other hematologic disorders with megaloblastic
findings in both peripheral blood smear and bone
marrow aspiration such as myelodysplastic anemia, liver
disease, and aplastic anemia.
It seems that evaluation of vitamin BI 2 and folate levels
in these patients would have been a necessary part
of diagnosis after observation of blood and bone marrow
smears that has been missed in this study.
B. It has been cited that a total primary number of 50
patients entered the study. Some of them have been ex-
cluded from the study due to existence of other diagnoses,
but not only have final numbers not been cited
but also all 50 have been included in the last extraction of
data, and no complementary patients were added.
Type of Study: Letter to Editor |
Subject:
General
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