Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Tue, Sep 8, 2026
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Volume 40, Issue 1 (1-2026)
Med J Islam Repub Iran 2026 |
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Khatuni M, Varaminian B, Ghoreyshi M, Ghalamkari M. Coagulation Disorders and Thrombotic Events in Patients with COVID-19: A Narrative Review. Med J Islam Repub Iran 2026; 40 (1) :729-735
URL: http://mjiri.iums.ac.ir/article-1-10010-en.html
URL: http://mjiri.iums.ac.ir/article-1-10010-en.html
Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran , dr.ghalam@yahoo.com
Abstract: (124 Views)
Background: This review explores the coagulation disorders and thrombotic events observed in COVID-19 patients, highlighting the underlying pathophysiological mechanisms and current management strategies.
Pathophysiology and clinical impact: Important mechanisms contributing to thrombosis include cytokine storm-induced thrombosis, antiphospholipid antibody syndrome, macrophage activation syndrome, complement cascade activation, and renin-angiotensin system dysregulation. Thrombotic complications significantly impact mortality and morbidity, with pulmonary emboli frequently observed in autopsy studies. Notably, this prothrombotic state may persist for weeks post-hospitalization.
Management: Effective management of COVID-19-associated coagulopathy requires prompt treatment of underlying infections and comprehensive assessment of co-infections in critically ill patients. While heparin and its derivatives remain the cornerstone for managing venous
thromboembolism, their efficacy for COVID-19-associated coagulopathy remains to be a subject of investigation.
Conclusion: Understanding the complex interplay between inflammation and thrombosis in COVID-19 is crucial for developing targeted therapeutic strategies that address coagulation disorders and the underlying infection.
Pathophysiology and clinical impact: Important mechanisms contributing to thrombosis include cytokine storm-induced thrombosis, antiphospholipid antibody syndrome, macrophage activation syndrome, complement cascade activation, and renin-angiotensin system dysregulation. Thrombotic complications significantly impact mortality and morbidity, with pulmonary emboli frequently observed in autopsy studies. Notably, this prothrombotic state may persist for weeks post-hospitalization.
Management: Effective management of COVID-19-associated coagulopathy requires prompt treatment of underlying infections and comprehensive assessment of co-infections in critically ill patients. While heparin and its derivatives remain the cornerstone for managing venous
thromboembolism, their efficacy for COVID-19-associated coagulopathy remains to be a subject of investigation.
Conclusion: Understanding the complex interplay between inflammation and thrombosis in COVID-19 is crucial for developing targeted therapeutic strategies that address coagulation disorders and the underlying infection.
: Review Article |
Subject:
Internal Medicine
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