Volume 8, Issue 1 (5-1994)                   Med J Islam Repub Iran 1994 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BOUZARI S, VATSALA B, VARGHESE A. CHA RA CTERIZATION OF VEROTOXIN-PRODUCING STRA INS OF ENTEROPATHOGENIC ESCHERICHIA COLI (EPEC) FROM CHILDREN WITH DIA RRHOEA: EFFECTS OF THE TOXIN ON RABB IT INTESTINE. Med J Islam Repub Iran 1994; 8 (1) :47-51
URL: http://mjiri.iums.ac.ir/article-1-1404-en.html
CHA RA CTERIZATION OF VEROTOXIN-PRODUCING STRA INS OF ENTEROPATHOGENIC ESCHERICHIA COLI (EPEC) FROM CHILDREN WITH DIA RRHOEA: EFFECTS OF THE TOXIN ON RABB IT INTESTINE
S BOUZARI , BR VATSALA , A VARGHESE
From the Molecular Biology Unit, Pasteur Institute of lran,
Abstract:   (4102 Views)
249 enteropathogenic Escherichia coli (EPEC) strains from faecal samples of 90 children with diarrhoea were examined for verotoxin (VT) production. Polymyxin B extracts of 61 strains belonging to 9 serogroups from 35 children produced various verotoxins (VTs). The titre of these various VTs ranged from I :40 to I: 12HO. Of the 26 (43.6%) adherent strains, 19 (73%) exhibited localized adherence (LA) and 7 (27%) manifested enteroadherent-aggregative (EA-Agg) patterns. The remaining 35 strains were nonadherent. Verotoxin producing EPECs elicited diverse effects on rabbit intestine ranging from no effect to severe damage to epithelial architecture, irrespective of their adherence patterns of HEp-2 cells. In conclusion, as far as EPEC pathogenesis is concerned, the role of verotoxins could not be established, but strains producing moderate to high levels of verotoxins may have an increased pathogenicity over non-producers.
Keywords: Verotoxins. Enterotoxins, EPEC, HEp-2
Full-Text [PDF 666 kb]   (1573 Downloads)    
Type of Study: Original Research: Basic Science in Medicine | Subject: Biological Sciences
Add your comments about this article : Your username or Email:
CAPTCHA
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.