ARDEHALl S, MOIN REZAKHANLOU A, SADEGHI E, TABEI S. STUDIES ON THE T-CELL PHENOTYPES IN CHILDREN WITH KALA-AZAR IN FARS PROVINCE, IRAN. Med J Islam Repub Iran 1993; 7 (3) :157-160
URL:
http://mjiri.iums.ac.ir/article-1-1422-en.html
From the Departments of MicrobiologyShiraz University of Medical Sciences, Shiraz, Islamic Republic of lran.
Abstract: (4545 Views)
The subpopulations of T-Iymphocytes were studied in children with visceral
leishmaniasis in the active stage of disease prior to treatment (n=28) and in controls
(n=15) using specific monoclonal antibodies (Behring OKT3, OKT4 and OKT8).
The percentage of total peripheral blood T-Iymphocytes (CD3+ T-cells) in patients
were within the same range as those of normal children (71.09± 1.07 vs68.89± 1.29).
The percentage of CD4+ T-Iymphocytes showed a significant increase (P<0.005) in
comparison with the control (53.92 ± 1.20 vs 45.59 ± 1.35). A decrease in the
percentage of CDS+ T-Iymphocytes (20.81 ± 0.71 vs 23.89 ± 0.72) was observed
which was significant at (P<0.025). The ratio of CD4+/CD8+T- lymphocytes was
significantly increased at P<0.005 as the value of the ratio was 2.70 ± 0.17 for kalaazar
patients and 1.91 ± 0.05 for the controls. The immunosuppression in kala-azar
patients studied could be due to dysfunction of antigen specific T-cells and its
subsequent effect on various cytokine release rather than changes in the phenotypic
characters of these cells.
Type of Study:
Original Research |
Subject:
Pathology