Form the Department of Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
Abstract: (4774 Views)
Aluminum is present in very small amounts in living organisms but abundant
in the environment. A growing literature links with the biochemistry of aluminum
and also with a series of diseases in chronic renal failure patients on treatment with
hemodialysis. The initial description of potential aluminum toxicity in renal
failure patients relates to description of dialysis encephalopathy syndrome in
1972. The major emphasise of this review will be on the recent literature involving
aluminum metabolism and epidemiology of aluminum related disease. Finally
the possibility that aluminum contributes to hypochromic microcytic anemia,
dialysis osteomalacia (Newcastle bone disease), encephalopathy and Alzheimer
disease in hemodialyzed patients has been also discussed.