Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
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Volume 16, Issue 3 (11-2002)
Med J Islam Repub Iran 2002 |
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BASIRI A, TABIBI A, PARVIN M. THE EFFECT OF URINE AND BLOOD METABOLIC RISK FACTORS ON CALCIUM STONE FORMATION. Med J Islam Repub Iran 2002; 16 (3) :133-137
URL: http://mjiri.iums.ac.ir/article-1-1630-en.html
URL: http://mjiri.iums.ac.ir/article-1-1630-en.html
From the Urology Research Center, Shahid Labbafi-Nejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
Abstract: (4481 Views)
In spite of vast improvements in urinary stone treatment (ESWL, PNL,
ureteroscopy, etc.), metabolic workup concerning the existence of stone forming
risk factors are of great importance and can lead to control and even prevention of
urinary stone formation in these patients.
In this analytical case-control study performed on 266 persons [110 normal
persons (56 males and 54 females), 76 patients with one episode of stone formation
(40 males and 36 females), and 80 patients with recurrent stone formation
(40 males and 40 females)] aged between 30 to 45 (with an average of 37.6) in
Shahid Doctor Labbafinejad Medical Center from May to July 1999, serum parameters
and 24-hour urine parameters have been investigated and compared
among the three groups. Results of this study revealed considerable differences in
urinary calcium levels of these three groups, with and without considering sex
(p<0.05). Averages of 24-hour urinary calcium calculated for normal, one episode
and recurrent stone formers in male groups were 159±43, 219± 71, and 283± 74
mg/24h respective1y, and for normal, one episode and recurrent stone formers in
female groups were 124±37, 190±58, and 287:t152 mg/24h respectively. Although
24-hour urine citrate in females obviously showed higher values than males, there
was no significant difference among the studied groups of the same sex. Levels of
serum calcium, potassium and magnesium between groups of females and 24-
hour urine magnesium and phosphate levels between groups of males had statistical
differences also (p<0.05 for all of the cases mentioned above).
According to the results obtained from this study, it was realized that in the
studied society levels of 24-hour urinary calcium which are higher than 200 mg/
24h (sensitivity 80%, specificity 94% and FPR 6.4%) and calcium creatinine ratios
of 24-hour urine which are higher than 0.17 (sensitivity 7.5%, specificity
88.1 % and FPR 11.9%) can be regarded as hypercalciuria. However, the results
of this study should be confirmed by more general and extended studies.
Type of Study: Original Research |
Subject:
Urology and Nephrology
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