Volume 28, Issue 1 (1-2014)                   Med J Islam Repub Iran 2014 | Back to browse issues page

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Farid Hosseini R, Jabbari Azad F, Yousefzadeh H, Rafatpanah H, Hafizi S, Tehrani H et al . Serum levels of vascular endothelial growth factor in chronic Obstructive pulmonary disease. Med J Islam Repub Iran 2014; 28 (1) :539-544
URL: http://mjiri.iums.ac.ir/article-1-2422-en.html
Serum levels of vascular endothelial growth factor in chronic Obstructive pulmonary disease
Reza Farid Hosseini , Farahzad Jabbari Azad , Hadis Yousefzadeh , Houshang Rafatpanah , Saeed Hafizi , Homan Tehrani , Masoud Khani
Mashhad University of Medical Sciences, Mashhad, Iran. , arc@mums.ac.ir
Abstract:   (3848 Views)

  Background :Chronic obstructive pulmonary disease (COPD) is a third leading cause of death.

  Methods : In this case control study, we prepared 5 cc bloods from the antecubital vein of 100 COPD patients and 40 healthy individuals as control group. Vascular endothelial growth factor (VEGF) expression protein level was measured by ELISA in both groups.

  Results : We found that concentration of VEGF in blood serum of patients with COPD (189.9±16pg/ml) was significantly higher than the control group (16.4±3.48pg/ml) (p<0.001). While VEGF serum level in emphysematous patients wasn’t significantly different with control group (p=0.07). Furthermore VEGF serum level in COPD patients was proportionally increased with severity of disease (p<0.001). Besides all COPD patients, regardless of their smoking status, were experienced significantly higher levels of VEGF than healthy ones (p=0.001 z=4.3).

  Conclusion : Our results suggest VEGF serum concentration as the sensitive index for severity and activity of COPD and its prognosis.

Keywords: Chronic obstructive pulmonary disease, Vascular Endothelial Growth Factor, Chronic bronchitis, Emphysema.
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Type of Study: Original Research | Subject: Pulmonary Disease
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