Volume 28, Issue 1 (1-2014)                   Med J Islam Repub Iran 2014 | Back to browse issues page

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Monavari S H, Mirzaeiparsa M J, Bolouri B, Ebrahimi S A, Ataei-pirkooh A. The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture. Med J Islam Repub Iran 2014; 28 (1) :641-645
URL: http://mjiri.iums.ac.ir/article-1-2453-en.html
The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture
Seyed Hamidreza Monavari , Mohammad Javad Mirzaeiparsa , Bahram Bolouri , Soltan Ahmed Ebrahimi , Angila Ataei-pirkooh
Department of Virology, School of Medicine, Iran University of Medical Sciences,Tehran, Iran. , hrmonavari@yahoo.com
Abstract:   (3874 Views)

  Background :Wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. Recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. We investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (HSV-1) in cell culture.

  Methods : In-vitro cytotoxicity study of empty niosomes (E-N), acyclovir loaded niosomes (ACV-N) and ACV as a free drug against HeLa cell line was performed by MTT assay and the viral titers was tested by TCID50 assay.

  Results : The results indicated that a significant higher antiviral activity for acyclovir loaded nano-niosomes of about 3 times in comparison with free drug.

  Conclusion : The results of this study revealed ACV-N have a higher antiviral activity compared with free drug it could be a suitable carrier for delivery of acyclovir in the treatment of HSV-1 infections.

 

Keywords: Nano-niosomes, Herpes simplex virus, Cytotoxicity.
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Type of Study: Original Research | Subject: Virology
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