Volume 19, Issue 4 (2-2006)
Med J Islam Repub Iran 2006 |
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Department of Nephrology, Tehran University of Medical Sciences, Imam Khomeini Hospital , f_ahmadish@yahoo.com
Abstract: (4909 Views)
Background: Calcineurin inhibitors (CNI) have significantly reduced the incidence
of acute rejection. Nephrotoxicity however may contribute to long-term allograft
dysfunction. Mycophenolate mofetil (MMF) may allow cyclosporine (CsA) dose reduction
without increasing the risk of rejection.
Methods: In seventy-eight living unrelated kidney transplant patients with renal
dysfunction, we studied the effect of CsA dose reduction in association with MMF on
renal function and cardiovascular risk profile.
Results: We reduced the cyclosporine dose from mean 3.5±0.94 mg/kg/d to
2±0.51 mg/kg/d,p
Type of Study: Original Research: Clinical Science |
Subject:
Nephrology
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