Volume 19, Issue 3 (11-2005)                   Med J Islam Repub Iran 2005 | Back to browse issues page

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KASHEF N, BEHZADIAN NEJAD Q. SYNERGISM BETWEEN 1-MEGAHERTZ THERAPEUTIC ULTRASOUND PL US CEFTAZ-IDIME ON GROWTH OF PSEUDOMONASAERUGINOSA. Med J Islam Repub Iran 2005; 19 (3) :251-254
URL: http://mjiri.iums.ac.ir/article-1-583-en.html
SYNERGISM BETWEEN 1-MEGAHERTZ THERAPEUTIC ULTRASOUND PL US CEFTAZ-IDIME ON GROWTH OF PSEUDOMONASAERUGINOSA
NASIM KASHEF , QORBAN BEHZADIAN NEJAD
Department of Bacteriology and the 2Department of Medical Physics, Tarbiat Modares , kashefn@modares.ac.ir
Abstract:   (4444 Views)
Objective: The effect of ceftazidime on Pseudomonas aeruginosa, with or without application of 1 MHz therapeutic ultrasound, was studied. Method: An aqueous suspension of microorganisms in a sterile, sealed plate was placed in an ultrasonic tank operating at 1 MHz. Different power outputs were used. After desired time of exposure to the ultrasound, each sample was plated separately and after incubation, the number of colonies was counted. Results: Results showed that ultrasound in combination with sMICs of ceftazidime was much more lethal to this bacterium than either of the treatments alone. The mechanism by which ultrasound enhances antibiotic action is due to the induction of uptake of antibiotic by perturbing or stressing the membrane. Conclusion: This application of ultrasound may be useful for expanding the number of drugs available for treating localized infections by rendering bacteria susceptible to normally ineffective antibiotics.
Keywords: Ceftazidime, Pseudomonas aeruginosa, Ultrasound
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Type of Study: Original Research: Basic Science in Medicine | Subject: Medical Physics and Radiation Therapy
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