Volume 18, Issue 3 (11-2004)                   Med J Islam Repub Iran 2004 | Back to browse issues page

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MOSALAEI A, AHMADLOO N, OMIDVARI S, MOHAMMADIANPANAH M. DOES HYPERFRACTIONATED RADIOTHERAPY CHANGE THE OUTCOME OF HEAD AND NECK CANCER? A TRIAL COMPARING CONVENTIONAL WITH HYPERFRACTIONATED RADIOTHERAPY. Med J Islam Repub Iran 2004; 18 (3) :231-235
URL: http://mjiri.iums.ac.ir/article-1-594-en.html
DOES HYPERFRACTIONATED RADIOTHERAPY CHANGE THE OUTCOME OF HEAD AND NECK CANCER? A TRIAL COMPARING CONVENTIONAL WITH HYPERFRACTIONATED RADIOTHERAPY
A MOSALAEI , N AHMADLOO , S OMIDVARI , M MOHAMMADIANPANAH
From the Radiatiol1 Oncology Department, Shiraz University of Medical Sciences, Shiraz, I.R. Iran . , mosalaa@sums.ac.ir
Abstract:   (4213 Views)
The optimal fractionation schedule for radiotherapy of head and neck cancer has been controversial. The objective of this randomized trial was to test the efficacy of hyperfractionation vs. standard fractionation. Patients with squamous cell carcinoma of head and neck organs were randomly assigned to receive radiotherapy delivered with A) standard fractionation at 2 Gy/fraction/day, 5 days/week, to 65-70 Gy/7 weeks B) hyperfractionation at 1.2 Gy/fraction, twice daily, 5 days/week to 75 - 80 Gy/7 weeks. All patients but one completed the treatment. The median follow-up was 24 months for all patients. Patients treated with hyperfractionation had significantly better local-regional control (p<0.005) than those treated with standard fractionation. Although acute morbidity was somewhat higher in the hyperfractionated radiotherapy group, late disturbing effect was much lower in this group. In conclusion, hyperfractionation is more efficacious than standard fractionation for locally advanced head and neck cancer. Acute but not late effects are also increased.
Keywords: Head and neck, Radiotherapy, Fractionation
Full-Text [PDF 112 kb]   (1466 Downloads)    
Type of Study: Original Research: Clinical Science | Subject: Oncology
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