Volume 18, Issue 4 (11-2005)                   Med J Islam Repub Iran 2005 | Back to browse issues page

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HADIZADEH F, ANARAKI-FIROOZ B, TAQAVI S. EFFECTS OF NOVEL 2-ALKYLAMINOSUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM . Med J Islam Repub Iran 2005; 18 (4) :361-364
URL: http://mjiri.iums.ac.ir/article-1-620-en.html
EFFECTS OF NOVEL 2-ALKYLAMINOSUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM
F HADIZADEH , BF ANARAKI-FIROOZ , SIH TAQAVI
From the Department of Medicinal Chemistry, Pharmacy Faculty, Mashhad University of Medical Sciences, P.O.Box 91775-1365, Mashhad, Iran , fhadizadeh@yahoo.com
Abstract:   (3880 Views)
In order to investigate the effects of dimethylamino substituent at position 2 of the dihydropyridine nucleus on activity, starting from dialkyl l ,4-dihydro-2,6-dimethyl-4- (l-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously, dialkyl l,4-dihydro-2-[2-(dimethylamino)ethyl]-6-methyl-4-(l-benzyl-2- alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (6a-f) were synthesized. Rabbit jejunum was used to determine the relaxant or antagonistic activity of the test compounds. The test compounds (6c-e) inhibited the spontaneous contractile activity dose-dependently and completely, while high-K+ contracted tissues were relaxed partially.
Keywords: 2-Dimethylamino-substituted dihydropyridines, Rabbit jejunum, Calcium Channel.
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Type of Study: Original Research: Clinical Science | Subject: Pharmacology
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