From the Department of Medicinal Chemistry, Pharmacy Faculty, Mashhad University of Medical Sciences, P.O.Box 91775-1365, Mashhad, Iran , fhadizadeh@yahoo.com
Abstract: (3767 Views)
In order to investigate the effects of dimethylamino substituent at position 2 of the
dihydropyridine nucleus on activity, starting from dialkyl l ,4-dihydro-2,6-dimethyl-4-
(l-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis
and effects as calcium channel antagonist on guinea-pig ileum has been reported
previously, dialkyl l,4-dihydro-2-[2-(dimethylamino)ethyl]-6-methyl-4-(l-benzyl-2-
alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (6a-f) were synthesized.
Rabbit jejunum was used to determine the relaxant or antagonistic activity of the
test compounds. The test compounds (6c-e) inhibited the spontaneous contractile activity
dose-dependently and completely, while high-K+ contracted tissues were relaxed
partially.