Medical Journal of The Islamic Republic of Iran (MJIRI)

  Abstract

  Background: Due to the high incidence of breast cancer and the effect of its early

  diagnosis on decreasing morbidity and mortality, we used the Gail model to study

  breast cancer risk in Iranian women.

  Methods: This study was done in a simple randomized way. Participants were 2000

  Iranian women older than 35 years old. The questionnaire consisted of demographic

  data such as age, race (optional ) marriage status , level of education and standard questions of the Gail model. Gathered data were given in http://bcra. nci. nih.gov/brc. The breast cancer risk was calculated within the next 5 years and within the 90 years life

  span. The statistical analysis was done by SPSS software.

  Results: Mean age of women in the study was 47.95 years .50% of women had their

  menarche at/older than fourteen years of age. 50% of women had first childbirth in

  their twenties. 87% had a negative family history of breast cancer. 94% had no history

  of breast biopsy. Of the remaining 6%, no tissue atypia was reported. In the present

  study, breast cancer risk within 5 years was 0.92% and the breast cancer risk within 90

  years of life was 9.14%. 7% showed risk of more than 1.67% in the Gail model. The

  age ranged between 55-65 years in this high risk group.

  Conclusion: In our study of breast cancer risk in Iranian women, breast cancer risk

  was lower than the control group in the Gail model estimate for 5 years and a 90-year

  life span. (0.92% versus 1.02% , 9.14% versus 11.21%). The differences were statistically significant (p<0.001).