Volume 16, Issue 3 (11-2002)                   Med J Islam Repub Iran 2002 | Back to browse issues page

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ZANDIEH T, TARABADI F, TABATABAIYAN A, IZADYAR M. A SURVEY OF CELLULAR IMMUNITY, TOTAL T-LYMPHOCYTE, T-ACTIVE , B-LYMPHOCYTE A ND T-CELL FUNCTION IN RELATION TO PHYTOHEMAGGLUTININ (PHA) IN THALASSEMIC PATIENTS. Med J Islam Repub Iran 2002; 16 (3) :169-172
URL: http://mjiri.iums.ac.ir/article-1-748-en.html
A SURVEY OF CELLULAR IMMUNITY, TOTAL T-LYMPHOCYTE, T-ACTIVE , B-LYMPHOCYTE A ND T-CELL FUNCTION IN RELATION TO PHYTOHEMAGGLUTININ (PHA) IN THALASSEMIC PATIENTS
T ZANDIEH , F TARABADI , A TABATABAIYAN , M IZADYAR
From the Iranian Blood Transfusion Service, Tehran , TZ7892000@Yahoo.com
Abstract:   (5755 Views)
The aim of this study was to evaluate the immune system and lymphocyte function in 41 Iranian β-thalassemic patients and 50 controls, ages ranging from 2 to 18 years. The patients consisted of 20 splenectomized and 21 non-splenectomized patients. They were treated with Desferal, and had received repeated blood transfusion. Laboratory investigations included measurement of total T lymphocytes, active T lymphocytes, B-Iymphocytes and function of lymphocytes treated with PHA. In this study we observed a significant reduction of active T lymphocytes and total T lymphocytes in the patient group compared to controls (p<0.005 & p<0.001), but there was no significant difference between splenectomized and non-splenectomized patients. Also in both groups, lymphocyte function was reduced against PHA (phytohemagglutinin) compared with the controls, and the numbers of B cells were increased. These results lead to the conclusion that the deficient immune system in β-thalassemia causes infectious diseases, which finally leads to death. Therefore, stimulation of the immune system as well as clinical treatment may prevent infectious disease in patients with β- thalassemia.
Keywords: Thalassemic patient, Immune system, Cytomegalovirus, Blood transfusion.
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Type of Study: Original Research: Basic Science in Medicine |
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