SARI ASLANI F, SALEHI M. DIFFERENTIATION BETWEEN MORPHOLOGICALLY AGGRESSIVE AND NON-AGGRESSIVE BASAL CELL CARCINOMA BY AgNOR STAINING. Med J Islam Repub Iran 2001; 15 (3) :139-142
URL:
http://mjiri.iums.ac.ir/article-1-795-en.html
From the Department of Pathology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Abstract: (4456 Views)
Argyrophilic staining of nucleolar organizer regions (AgNOR) has been considered
to be useful in the diagnosis and prognostic evaluation of different cutaneous
tumors. In order to evaluate the role of the AgNOR technique in discriminating
aggressive from non-aggressive basal cell carcinoma (BCC), paraffin-embedded
histologic sections from 30 cases of aggressive BCC (BCC2) and 30 cases
of non-aggressive BCC (BCC 1) were investigated for nucleolar organizer regions
(NOR), and these cases were categorized on the basis of histologic criteria. The
means of AgNOR counts were higher in BCC2 than BCC1 without overlapping
in the range of NOR numbers. In BCC2 the majority of the dots had irregular
borders and were of varying sizes, whereas in BCC 1, the dots had regular borders
with little variation in size.
The means of AgNOR counts were 4.81 with an SD (standard deviation) of
0.88 for aggressive and 2.39 with an SD of 0.61 for the non-aggressive group.
The difference was statistically significant (p value= 0.000).
The AgNOR number, their configuration and size, may provide information
to be useful for recognition of aggressive BCC. Considering histologic criteria,
AgNOR counting and clinical features, we can predict the behavior of most BCC
tumors.
Type of Study:
Original Research |
Subject:
Pathology