ZARRINDAST M, HASHEMI B, TOLUI V. EFFECTS OF DOPAMINE RECEPTOR AGONISTS AND ANTAGONISTS ON BACLOFEN-INDUCED ANTINOCICEPTION IN FORM ALIN TEST. Med J Islam Repub Iran 2000; 14 (1) :69-75
URL:
http://mjiri.iums.ac.ir/article-1-903-en.html
From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.
Abstract: (4393 Views)
In this study, the influence of dopamine receptor agonists and antagonists on
antinociception induced by bac10fen has been examined in the formalin test. The
GABA-B agonist bac10fen induced antinociception in both phases of the formalin
test in mice. The dopamine receptor agonists SKF 38393 and quinpirole also
induced antinociception in both phases of the test. SKF 38393 but not quinpirole
potentiated the response to bac10fen in the first phase of the test. The dopamine
receptor antagonists SCH 23390 and sulpiride increased the response to baclofen
in the first phase. Both drugs induced antinociception in the first phase of the
fonnalin test. However, low doses of sulpiride increased the pain response in the
second phase. The peripheral dopamine receptor antagonist domperidone did not
alter the effect of the test by itself. Dopamine receptor mechanisms appear to
interact with baclofen-induced antinociception.