Showing 10 results for Aslani
M. Mehdi Aslani, Reza Gharagozloo,
Volume 9, Issue 3 (10-1995)
Abstract
In a clinical trial a new pyrrolidonyl-β-naphthylamide (PYR) hydrolysis test
was compared with the bacitracin disk susceptibility test for accuracy in the
presumptive identification of group A streptococci (GAS). Among 128 isolates of
beta-hemolytic streptococci 93 group A isolates were found. The sensitivity of the
PYR and bacitracin tests were similar (98.9%), but the bacitracin test had a lower
specificity (80%) than the PYR test (100%). The efficiency of the PYR and
bacitracin test were 99.2% and 93.7%, respectively. All bacitracin tests were
performed on subcultures of the isolates from the primary plate, whereas PYR
testing was performed on colonies from the primary plate. This shortened the
turnaround time for the PYR test compared to the bacitracin test by at least 24
hours.
F Sari Aslani, B Salimi,
Volume 14, Issue 3 (11-2000)
Abstract
To investigate the patterns of DNA ploidy and proliferating activity in breast
cancer and relate them to other prognostic factors, paraffin blocks of 53 cases of
breast carcinoma were studied. Cancer cells obtained by mechanical tissue disaggregation
were examined for DNA content, ploidy and S-phase fraction. DNA
assay was done using a CAS interactive image analyzing system.
All of the cases showed high degrees of proliferation. The rate of aneuploidy
was 77% in invasive breast carcinomas. S-phase fractions were correlated with
the grades of the tumors (p
F Sari Aslani, A Aledavood,
Volume 15, Issue 2 (8-2001)
Abstract
Basal cell carcinoma (BCC) is currently the most common cutaneous cancer
found in humans. Although it generally shows a relatively benign course (BCCl),
some cases show aggressive behavior (BCC2). Until recently, traditional histologic
diagnostic criteria have failed to discriminate unequivocally between BCC 1
and BCC2.
In this study we selected 50 cases of BCC and categorized them into two
groups (BCCl and BCC2) on the basis of histologic criteria and then examined
the rate of angiogenesis to establish if it correlates with their histological features
and/or clinical behavior. The vessels were highlighted by immunohistochemical
staining for factor VIII-related antigen in formalin fixed paraffin embedded tissues.
All 25 cases of BCC2, whose clinical behavior was aggressive had
microvessel counts significantly higher than that of the BCC I group with mean
values of 50.24 and 20.9 for BCC2 and BCCl respectively. But there were eight
cases of morphological BCCI who had aggressive clinical behavior and interestingly
had microvessel counts higher than the other cases of BCC 1.
The findings of the present study seem to establish a correlation between
tumor angiogenesis and clinicobiologicaI parameters of aggressiveness.
From this point of view the assay of microvessel density might be helpful in
selecting patients with BCCs at high risk for recurrence or metastasis, who could
benefit from additional therapies and closer followup.
F Sari Aslani, M Salehi,
Volume 15, Issue 3 (11-2001)
Abstract
Argyrophilic staining of nucleolar organizer regions (AgNOR) has been considered
to be useful in the diagnosis and prognostic evaluation of different cutaneous
tumors. In order to evaluate the role of the AgNOR technique in discriminating
aggressive from non-aggressive basal cell carcinoma (BCC), paraffin-embedded
histologic sections from 30 cases of aggressive BCC (BCC2) and 30 cases
of non-aggressive BCC (BCC 1) were investigated for nucleolar organizer regions
(NOR), and these cases were categorized on the basis of histologic criteria. The
means of AgNOR counts were higher in BCC2 than BCC1 without overlapping
in the range of NOR numbers. In BCC2 the majority of the dots had irregular
borders and were of varying sizes, whereas in BCC 1, the dots had regular borders
with little variation in size.
The means of AgNOR counts were 4.81 with an SD (standard deviation) of
0.88 for aggressive and 2.39 with an SD of 0.61 for the non-aggressive group.
The difference was statistically significant (p value= 0.000).
The AgNOR number, their configuration and size, may provide information
to be useful for recognition of aggressive BCC. Considering histologic criteria,
AgNOR counting and clinical features, we can predict the behavior of most BCC
tumors.
L Dastgheib, P Peyravi, Fs Aslani,
Volume 16, Issue 1 (5-2002)
Abstract
Autoerythrocyte sensitization syndrome CABS) is a rare purpuric disorder of
women characterized by inflammatory and painful ecchymotic lesions unrelated
to blood clotting or vascular abnormalities. Gastrointestinal bleeding, hematuria,
headache or syncopal attacks may also be observed.
Our patient is a 33-year-old woman presenting with recurrent severe painful
ecchymotic lesions on both lower extremities associated with headache, palpitation
and weakness. The diagnosis of AES was confirmed by skin testing with
autologous washed red blood cells. No internal bleeding was detected. She was
treated with vitamin C with some success.
Hamid Reza Aslani, Hamed Vahedi, Zohreh Zafarani,
Volume 23, Issue 2 (8-2009)
Abstract
Abstract
Background: Rotator cuff tear is one of the most common causes of shoulder
complaints in the elderly. Based on the severity and patient's condition, a variety of
methods applies to manage the tear and surgery is an important method, which could
be done by open or arthroscopic technique. The current study aimed to investigate
and report short-term results of arthroscopic repair of complete rotator cuff tears.
Methods: This was a cross-sectional study on 183 patients who underwent arthroscopic
surgery to repair rotator cuff tear in three different hospitals of Tehran between
January 2003 and August 2006. Of all patients, 107 cases included in our
study, which had a complete rotator cuff tear, and at least one-year follow up record.
89 patients (56 male and 33 female) attended assessment sessions and were evaluated
by UCLA(University of California, Los Angeles) Shoulder and Elbow Scoring System,
pre- and post-operatively, and acromioplasty was performed in 83 patients.
Results: With a mean age of 53.2 ± 15.8 (32-71) years, the average UCLA score
was 11.3 before the surgery and 31.4 post-operatively. There were 11 patients with
excellent scores, 62 good, 11 fair, and 5 poor scores. 9 out of 11 cases with excellent
score and 34 out of 62 with good score were younger than 55 years however, 13 cases
were older than 60 years amongst 16 fair or poor scores.
Conclusions: Arthroscopic repair of complete rotator cuff tear would cause a significant
improvement in a short-term period and results are better in younger patients,
through the UCLA scoring system.
Hamid Reza Aslani, Hamid Farrokhi, Zohreh Zafarani,
Volume 23, Issue 3 (11-2009)
Abstract
Abstract
Background: Despite being the largest rotator cuff tendon of the shoulder, the
function and clinical relevance of subscapularis pathology has been largely ignored
in the literature. Although many studies have focused on subscapularis tears recently,
majority of them reported techniques for open repair. The advent of arthroscopy and
arthroscopic repair techniques has opened new frontiers in the diagnosis and repair of
torn rotator cuff tendons, including the subscapularis. In this article, we review shortterm
results of arthroscopic subscapularis repair.
Method: Ten patients with subscapularis tendon tear of the rotator cuff were studied
prospectively including 8 men and 2 women with an average age of 49.7±12.8
years and an average delay in treatment of 23.3 months. Clinical outcomes, including
the UCLAscore were assessed in all patients after 3 months of the surgery.
Results: 6 patients were followed regularly for more than 6 months, while other 4
patients had a follow-up period of more than a year. The pain score improved from
1.75 to 9 and the UCLA score from 8.8 to 30.6.
Conclusions: Arthroscopic repair of subscapularis tendon tear results in significant
subjective and objective improvement and high levels of patient satisfaction.
Fatemeh Sari Aslani, Bita Geramizadeh, Amir Reza Dehghanian,
Volume 29, Issue 1 (1-2015)
Abstract
Background: Melanoma causes the greatest morbidity and mortality of all skin cancers. Mucosal melanoma is a rare but highly aggressive neoplasm. According to previous studies the prevalence of KIT mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. Our goal was to evaluate c-Kit expression in different types of primary and metastatic melanoma to discriminate potential candidates for targeted therapy.
Methods : We designed a cross-sectional study and selected 50 cases of malignant melanoma (primary, metastatic cutaneous, and mucosal) from the affiliated hospitals of Shiraz University of Medical Sciences in the period of 2008 to 2012. Immunohistochemistry for KIT expression was performed. Multistage sampling method was selected for sampling and chi-square test was used for statistical analysis.
Results : In our study, male to female ratio was 1.77. The male sex was correlated with higher tumor stage (p<0.05). 62% (n=31) of cases showed at least 5% of KIT-positive cells, consist of 18% (n=9) with 5–50%, 16% (n=8) with 51–95%, and 28% (n=14) of cases showed more than 95% of cells expressing KIT. But in 38% (n=19) of cases KIT expression was less than 5% of positive cells. Tumor stage was positively correlated with tumor cell immunoreactivity and intensity (p<0.05). Metastatic melanoma showed lower percentage (43%) of positivity. Intensity of staining and percentage of positive cells were positively correlated (p<0.001).
Conclusion : In primary melanomas, significant KIT expression was found by immunohistochemistry, which may be useful to screen the patients for advising to KIT mutation analysis and targeted therapy.
Seyed Ali Javad Moosavi, Jafar Aslani, Zahra Aslani, Hanieh Raji,
Volume 35, Issue 1 (1-2021)
Abstract
Background: Impulse oscillometry (IOS) is a method that does not depend on the cooperation of the patient and can detect small airway diseases with higher sensitivity than spirometry. However, the clinical application value of IOS in the screening of patients exposed to risk factors COPD and early diagnosis remains unclear. The aim of this study is to evaluate diagnostic sensitivity of IOS in the early detection of patients exposed to risk factors COPD.
Methods: A prospective cross-sectional study was conducted in Rasoul Akram Hospital, Tehran, Iran, from 2013 to 2015. 28 patients with COPD risk factors and normal spirometry participated in the study. The IOS was performed. We obtained the respiratory resistance and impedance of 5 Hz (R5) and 20 Hz (R20) and 5 Hz (Z5), respectively. The data were analyzed using SPSS version 17 using Chi-square and two independent sample t-test. Spearman correlation test was used to measure the correlation of oscillometry parameters in the diagnosis of COPD. P-value <0.05 was considered significant for all statistical analyses.
Results: The mean patient age was 55.50±11.27 years. In this study, the sensitivity of Z5, R5, and R20 was respectively 28.5%, 25%, and 31.5%. All oscillometry parameters were significantly correlated with each other but none of the oscillometry parameters showed significant correlations with FEV1/FVC (rZ5=0.018, rR5=0.082, rR20=0.041 and PZ5=0.932, PR5=0.711, P R20=0.850). According to the results, only 9 patients (32.5%) with normal values of FEV1/FVC had abnormal values of oscillometry.
Conclusion: IOS has a low sensitivity and cannot be used in the screening of early-stage chronic obstructive pulmonary disease.
Nasim Aslani, Ali Behmanesh, Ali Garavand, Masoumeh Maleki, Freshteh Davoodi, Roshanak Shams,
Volume 36, Issue 1 (1-2022)
Abstract
Background: Virtual Reality (VR) as an emerging and developing technology has received much attention in healthcare and trained different medical groups. Implementing specialized training in cardiac surgery is one of the riskiest and most sensitive issues related to clinical training. Studies have been conducted to train cardiac residents using this technology. This study aimed to identify the effects and features of VR technology in cardiology interventions training.
Methods: This scoping review was conducted in 2021 by searching PubMed, Scopus, and Web of Sciences scientific databases by combining the related keywords. A data extraction form was used for data gathering. Data analyses were done through the content analysis method, and results were reported based on the study objectives.
Results: 21 studies were included; from the 777 articles found in the initial searches, seven (33.33%) were RCT studies. VR-based education studies in cardiology interventions have grown significantly in recent years. The main effects of applying VR include improved user attitude and satisfaction, improved performance after VR training, and improved training and learning. Input devices include tracking devices, point input devices, and controllers. Output devices were three main categories include graphics audios and haptic.
Conclusion: The use of new technologies, especially VR, can improve the efficiency of medical training in clinical settings. It recommends that this technology train the necessary skills for heart surgery in cardiac residents before performing real surgery to reduce the potential risks and medical errors.
