Showing 7 results for Heidarzadeh
Majid Davari, Bahman Amani, Fariborz Mokarian, Mohsen Hoseini, Arash Akbarzadeh, Nastaran Heidarzadeh Khoramabadi,
Volume 31, Issue 1 (1-2017)
Abstract
Background: Trastuzumab in combination with chemotherapy has long been established as a standard treatment for HER2-positive patients in early stage breast cancer (BC). The present study aimed at assessing the effectiveness of trastuzumab adjuvant therapy in early stage BC in overall survival (OS) and disease-free survival (DFS).
Methods: A systematic review and meta-analysis was performed to evaluate the effectiveness of trastuzumab adjuvant therapy. PubMed, Cochrane library, Scopus, Web of Science, and Embase databases were searched for relevant RCTs from the beginning to February 2017. Quality assessment of studies was conducted using the Cochrane Risk of Bias Tool. The desired outcomes were OS and DFS.
Results: A total of 1818 articles were identified first, however, only 11 studies were eligible to be included in this study. Our findings and meta-analysis results revealed that trastuzumab is effective in increasing OS (OS hazard ratio: -0.286 ± 0.049, 95%CI (-0.381, -0.191)) and improving DFS (DFS hazard ratio: -0.419± 0.077, 95%CI (-0.569, -0.269)). The most serious but negligible side effect of trastuzumab is congestive heart failure.
Conclusion: Adding trastuzumab as adjuvant therapy in early stages of BC in HER2 positive patients could increase OS and DFS of the patients effectively.
Narjes Khalili, Maziar Moradi-Lakeh, Mohammad Heidarzadeh,
Volume 33, Issue 1 (2-2019)
Abstract
This is a letter to editor in responce to review article entitled " Low birth weight in Iran: Implications from a systematic review of the literature and meta-analysis in the period 1999-2017" by Ebadi et al. published in the Medical Journal of the Islamic Republic of Iran (2018; 32 (1): 68-77).
Narjes Khalili, Mohammad Heidarzadeh, Abbas Habibelahi, Batool Tayefi, Mozhdeh Ramezani, Zahra Rampisheh, Arash Tehrani-Banihashemi, Fariba Mirbaha, Farima Raji, Ebrahim Babaee, Rahim Taghizadeh Asl, Maziar Moradi-Lakeh, Mohsen Naghavi, Ali H. Mokdad,
Volume 34, Issue 1 (2-2020)
Abstract
Background: Under Every Newborn Action Plan (ENAP), stillbirth rate in every country should be reduced by 12 or fewer per 1000 total births by 2030. The aims of this study were to determine stillbirth rate at national and subnational levels and to investigate its associated risk factors in Iran.
Methods: Using all data from Iranian Maternal and Neonatal Network (IMaN), we calculated stillbirth rate of Iran from 2014-2016. This network registers information of almost all births across the country. The logistic regression was used to estimate the adjusted odds ratio (aOR) with 95% confidence intervals (CIs) for stillbirth.
Results: In 2014, still birth rate was 7.40 per 1000 births. In 2015 and 2016, stillbirth rates were 7.22 per 1000 births and 7.63 per 1000 births, respectively. The most important related factors of stillbirth were preterm birth (aOR= 62.53, 95% CI; 60.77-64.34), sexual ambiguity (aOR= 14.51, 95% CI; 12.76-16.50), and post term birth (aOR= 3.31, 95% CI; 2.66-4.13).
Conclusion: Under Every Newborn Action Plan (ENAP), stillbirth rate in every country should be reduced by 12 or fewer per 1000 total births by 2030. Iran has achieved stillbirth target of ENAP at national level. It is important for the health care system to establish and improve specific and focused policies, interventions, and programs for achieving this target even in the most deprived areas.
Forouzan Akrami, Gohar Mohammadi, Mehdi Azizmohammad Looha, Abbas Habibelahi, Yadollah Mehrabi, Shahnaz Delbarpoor Ahmadi, Mohammad Heidarzadeh,
Volume 35, Issue 1 (1-2021)
Abstract
Background: Estimation of the survival of very preterm infants is necessary to make decisions and design interventions in order to improve their quality of care. This survey aimed to estimate the survival of very preterm infants born at 23 up to 33 weeks of gestational age (GA) in Iran.
Methods: This population-based retrospective cohort study included 8536 infants born before 33 weeks of GA, from March 21st to December 22nd 2013 in Iran. The primary data were extracted from the Iranian national maternal and neonatal registration network (IMAN). All infants who have been discharged alive, followed up by telephone contact up to one year after birth. The Kaplan-Meier and Log-rank tests were performed to estimate survival and to compare survivals, respectively, using SPSS version 26 and R 3.5.2 softwares.
Results: The overall survival was estimated at 56.70% (95% C.I: 55.60%-57.80%) at the end of the follow-up period. Total death rate was estimated at 43.30% and was significantly decreased with increasing birth weight (p<0.0001). Survival was increased significantly with increasing GA (p<0.0001), from 5.7% at 23 weeks to 79.6% at 32 weeks. The estimated cumulative proportion of death until the end of the neonatal period had a decreasing trend and then had a steady trend until the end of the follow-up period. The hazard ratio of quadruple or more birth and GA were 1.46 (p=0.021) and 0.83 (p<0.001), respectively.
Conclusion: The overall estimated survival of very preterm infants was not high. Even with modern perinatal technology and care, early deaths of very preterm infants were still common.
Abtin Heidarzadeh, Bita Hedayati, Mehdi Alvandi, Mostafa Rezaei, Babak Farrokhi, Ideh Dadgaran, Mark K. Huntington, Shadrokh Sirous, Roksana Mirkazemi,
Volume 37, Issue 1 (2-2023)
Abstract
Background: Iran has implemented the Family Physician Program (FPP) in 2005 in 4 provinces. This program was supposed to be expanded across the country; however, it faced various challenges. Considering the impact of the referral system on the quality of the FPP implementation, different studies were conducted to evaluate the performance of this system. Therefore, this systematic review of the literature was conducted to investigate the challenges of the referral system of the FPP in Iran.
Methods: All published original articles, reviews, or case studies published in English or Persian related to the challenges in the referral system FPP in Iran from 2011 to September 2022 were included in this study. International credible scholarly databases were searched. The search strategy was defined based on keywords and the search syntax.
Results: Out of 3910 articles identified by the search strategy, considering the inclusion and exclusion criteria and relevance of the study, and accreditation of the studies, 20 studies were included. The referral system suffers from different challenges in the areas associated with policy and planning, management, referral process, and health service recipients.
Conclusion: The inefficient gatekeeping role of family physicians was one of the most important challenges of the referral system. The referral system should be improved by having evidence-based guidelines and policy documents, unified stewardship, integrated insurance schemes, and effective communication between different levels of care.
Mohsen Seifollahi, Marzieh Heidarzadeh Arani, Rozita Hoseini Shamsabadi, Shahrbanoo Nakhaie, Maesoumeh Karimi Aghche, Mohammad Javad Azadchehr, Amin Sadat Sharif,
Volume 38, Issue 1 (1-2024)
Abstract
Background: Urinary tract infections (UTIs) are extremely prevalent bacterial infections among children. They have numerous potential causes. Without proper diagnosis and treatment, UTIs can lead to serious complications in children, including impaired growth, high blood pressure, protein in urine, and eventual chronic kidney disease. Zinc and vitamin D in sufficient concentrations help to maintain the health of the immune system. Therefore, their deficiency can cause various infections. Several factors can contribute to the development of UTIs. This article deals with the role of zinc and vitamin D as immune markers in UTI in children without other risk factors.
Methods: In this case-control study, serum zinc and vitamin D levels without any other risk factors were examined in 40 healthy children and 40 children with UTIs. Data analysis was done through SPSS 26 using the chi-square, the Fisher’s exact, and independent t tests.
Results: The study findings demonstrated a statistically significant distinction between the 2 groups regarding serum vitamin D and zinc levels (P < 0.001); 80% of children with UTIs and 17.5% in the healthy group had vitamin D deficiency. Also, 60% of the urinary infection group had zinc deficiency, whereas 17.5% of the healthy group had it.
Conclusion: Low serum zinc and vitamin D levels may increase susceptibility to pediatric UTI. Given the data, supplementation with zinc and vitamin D could play a significant role in treating active infections and preventing recurrence in susceptible children.
Babak Sabet, Mahdi Aghabagheri, Abtin Heidarzadeh, Ebrahim Kalantar, Marzieh Nojomi,
Volume 39, Issue 1 (1-2025)
Abstract
Considering all medical schools in the nation and the preparation of the third round, which will begin in the coming months, a review of the accreditation of undergraduate medical education programs in Iran has identified both opportunities and threats with regard to the 2 previous rounds.
The prediction of the third round will not result in quality assurance or improvement for medical schools if the aforementioned opportunities and threats are not carefully examined. This is due in part to a misinterpretation of the nature of accreditation, which is an expertise model, where expertise is the matter of competence, competency, knowledge, skills, and attitude that must be examined in compliance with the well-organized criteria.
