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Showing 2 results for MOADDAB
SPECIES IDENTIFICATION AND INV ESTIGATION OF VANCOMYCIN AND HIGH-LEVEL AMINOGLYCOSIDE AMONG CLINICAL ISOLATES OF ENTEROCOCCAL STRAINS
Sr Moaddab, A Rafi,
Volume 16, Issue 3 (11-2002)
Abstract
A study was performed to determine the species and antimicrobial susceptibility of 100 enterococcus strains from various clinical specimens as etiological agents at the Clinical Microbiology Laboratory, Istanbul University, Medical Faculty Hospital. Out of 100 enterococcal isolates, 86 were identified as E. faecalis, 11 as E. faecium, 1 as E. avium and 2 as E. raffinosus. By the disk diffusion tests 36 of 100 strains were found to be resistant to erythromycin, 32 to penicillin, 30 to ampicillin, 7 to ciprofloxacin, 6 to norfloxacin and 5 to nitrofurantoin. No resistance was observed to vancomycin or teicoplanin. Twenty-six strains showed high-level resistance to streptomycin (2000 )..lg/mL) and 13 strains exhibited high-level resistance to gentamicin (500 )..lg/mL). Ten of these strains had high-level resistance to both aminoglycosides. None of the strains produced beta -lactamase.
A STUDY OF MYCOBACTERIUM TUBERCULOSIS DRUG RESISTANCE IN PULMONARY TUBERCULOSIS
Sr Moaddab, A Rafi,
Volume 17, Issue 3 (11-2003)
Abstract
Tuberculosis remains a major public health problem in both developing and developed countries. Drug-resistant tuberculosis is an increasing health problem and serious challenge to tuberculosis (TB) control programs. Information about the susceptibility pattern of Mycobacterium tuberculosis isolates against anti-tuberculosis drugs is an important aspect to TB control. The objectives of the study were to evaluate the frequency of drug-resistance and to survey the nature of drug resistance among patients with pulmonary tuberculosis. Ninety-one M. tuberculosis strains were isolated from sputum samples of patients referred to Cerrhapasa Medical Faculty Hospital, Istanbul, Turkey, during a 9 month period. Drug susceptibility testing was performed to isoniazid (INH), streptomycin (SM), ethambutol (EMB) and rifampin (RMP) on Lowenstein-Jensen medium according to proportion method. Total resistance was identified in 40 of 91 patients (44%). The highest rate of primary resistance was to SM (21.1 %), followed by INH (15.8%), RMP (5.3%) and EMB (2.6%). Secondary resistance was most frequent to INH (33.3%), followed by SM (28.6%), RMP (23.8%) and EMB (14.3%). Multidrug resistance (MDR) was observed in 6 of the 91 cases (6.6%). Due to the high prevalence of drug resistance, particularly in developing countries, further studies should be conducted regularly to monitor resistance in these countries.
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