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Combined effect of polymorphic sites in the DTNBP1 and GRIN1 genes on schizophrenia
Hamid Galehdari, Tahereh Ajam, Atefeh Pooryasin, Ali Mohammad Foroughmand, Seyed Reza Kazeminejad,
Volume 24, Issue 1 (5-2010)
Abstract

 

  Abstract

  Background: Schizophrenia is a severe mental disorder and numerous genes and loci

  are beleived to be involved in this disease. Recent studies have reported a strong genetic association between DTNBP1 (dystrobrevin-binding protein 1) gene variants and schizophrenia.

  Methods: In this research, we used a case-control study to establish the possible association between the P1635 (rs3213207) polymorphism in the DTNBP1 gene and schizophrenia in an Iranian cohort of 200 unrelated patients and 200 controls. The allele and genotype frequencies of the polymorphism in the two groups were determined using

  PCR-RFLP and the data analyzed using logistic regression and Mantel-Haenszel chisquare tests.

  Results: The additive effect of the P1635 polymorphism in DTNBP1 and the previously

  reported G1001C polymorphism in the GRIN1 gene were investigated. Analysis of data

  revealed a strong association between the P1635 polymorphism and schizophrenia

  (AG genotype: OR=0.39, 95% CI= 0.24-0.62, P<0.001).

  Conclusion: Our results indicated that the coexistence of the Aand C alleles from the

  two polymorphisms, P1635 and G1001C, increase the risk for schizophrenia.

 


Association study between schizophrenia and the DISC1 gene polymorphism
Ali Mohammad Foroughmand, Maryam Haidari, Hamid Galehdari, Atefeh Pooryasin, Seyed Reza Kazeminejad, Shiva Hosseini, Nahid Khajeh-Mogehi,
Volume 24, Issue 1 (5-2010)
Abstract

  Abstract

  Background: The disrupted-in-schizophrenia 1 (DISC1) gene, on the chromosome

  position 1q42, was initially identified at the breakpoint of a balanced translocation,

  t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large

  Scottish family.

  Methods: Our samples included 200 unrelated patients diagnosed with Schizophrenia

  on the basis of DSM-IV criteria and 200 normal controls, which were gathered

  from Iran. The allele and genotype frequencies of the polymorphism were determined

  using Polymerase Chain Reaction-Restricted Fragment Length Polymorphism

  (PCR-RFLP) and the data were analyzed by Logistic Regression test.

  Results: In this study we genotyped the rs821616 polymorphism (Serin704Cystein)

  located within exon 11 of the DISC1 gene. The samples were matched on the basis

  of sex and ethnicity. We used the case control study to determine the possible association between the ser704cys (rs821616) polymorphism and Schizophrenia. Analysis of data in the samples, revealed no association between the rs821616 polymorphism and Schizophrenia (OR= 0.697, 95% CI= 0.47-1.033, P=0.072).

  Conclusion: In this study we did not find any association between the rs821616

  SNPand schizophrenia.

 


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