Showing 8 results for Sagha
Fatemeh Davari-Tanha, Saghar Samimi-Sede, Zohre Khalilpour, Fatemeh Khanmohamadi, Jalle Mohamadpour,,
Volume 22, Issue 2 (8-2008)
Abstract
Abstract
A32 year-old multigravid patient with 10 weeks of pregnancy was referred to the emergency ward with massive vaginal bleeding and preshock state. Suction curettage, laparotomy, uterine artery ligation, Macdonald cerclage, and hysterectomy was done, in that order. After hysterectomy and massive transfusion she recovered. When a diagnosis of cesarean scar pregnancy is made in the emergency state and especially in the presence of underlying disease, morbidity is high and fertility lost.
Maryam Beheshtian, Ardeshir Khosravi, Alireza Olyaeemanesh, Hossein Malekafzali, Shirin Bonakdar Esfahani, Leila Hosseiny Ghavamabad, Saeideh Aghamohammadi, Mahnaz Nouri, Elaheh Kazemi, Mohammadreza Zakeri, Fatemeh Sagha,
Volume 29, Issue 1 (1-2015)
Abstract
Background: An obvious gradient in health outcomes has been implicated in many evidences relating to social and economic factors. Proper data are requested to convince policy-makers calling for intersectoral action for health. Recently, I.R. of Iran has come up with 52 health equity indicators to monitor health equity through the country. Conducting regular surveys on 14 out of 52 national health equity indicators is needed to provide a basis for the health inequality analysis through the country. We aimed to introduce a survey tool and its related protocols on health equity indicators.
Methods: This study was conducted through addressing the literature and expertise of health and demographic surveys at the national and international levels. Also, we conducted technical and consultative committee meetings, a final consensus workshop and a pilot study to finalize the survey tool.
Results: We defined the study design, sampling method, reliable questionnaires and instructions, data collection and supervision procedure. We also defined the data analysis protocol on health equity indicators, generated from non-routine data.
Conclusion: A valid and reliable tool, which could be employed at the national and sub-national levels, was designed to measure health equity in Iran. Policy-makers can use this survey tool to generate useful information and evidence to design appropriate required intervention and reduce health inequality across the country.
Mostafa Hosseini Golkar, Seyed Sepehr Ghazinoory, Fatemeh Saghafi, Mohammad-Rahim Eivazi, Atousa Poursheikhali, Reza Dehnavieh,
Volume 31, Issue 1 (1-2017)
Abstract
Background: Scenario is the primary method in futures studies, and thus its improper use can undermine the credibility and claims of the results. There are many scenario types, and here we aimed at understanding whether these scenarios are being used properly in the health field.
Methods: In this study, a combination method was used in 3 phases, and 8 + 2 steps were considered to accommodate the needs of the health sector with capabilities of the main types of scenarios. One of the appropriate methods of futures studies was used at each step.
Results: Scenario planning has evolved along with futures studies paradigms. Trend-based scenarios, intuitive logic, and structural analysis approaches have had the most use in futures scenarios and health section. Quantitative techniques, which are close to the positivist paradigm, have been most widely used; however, participatory methods of futures studies paradigm have been used the least in the health sector.
Conclusions: Health scenario writing in its current state is targeting short- to medium- term futures and does not respond to all requirements. Thus, other backup methods should also be considered.
Maryam Rahimi, Farkhondeh Behjati, Nazanin Taheri, Shadi Hosseini, Hamid Reza Khorram Khorshid, Fatemeh Aghakhani Moghaddam, Masoud Karimlou, Saghar Ghasemi, Niloofar Bazazzadegan, Fereidoon Sirati, Elahe Keyhani,
Volume 32, Issue 1 (2-2018)
Abstract
Background: PI3K/Akt/mTOR pathway is a crucial pathway in the angiogenesis, tumour growth and cell differentiation of several cancers. The PI3K and KIT genes are key genes of this pathway. Previous studies have reported the importance of these genes in the development of gastrointestinal carcinoma, leukaemia, and melanomas. The role of mutations and overexpression of PI3K and KIT genes in breast cancer has been previously proved. This study investigates the correlation between PI3K and KIT gene mutations in sporadic breast cancer.
Methods: Multiplex Ligation-dependent Probe Amplification (MLPA) technique was used to determine the Copy Number Variation (CNV) of PI3K and KIT genes in 34 breast cancer tumours and PCR-sequencing was used to detect the mutation in PI3K exons 9 and 20.
Results: Our results reported that 27% of patients had CNV of the KIT gene; whereas, 20% and 17.5% of patients, had mutation and CNV in the PI3K gene, respectively. We did not found a significant correlation between the mutations of PI3K and KIT genes.
Conclusion: About two-tenth of the patients revealed CNV and lesser than two-tenth indicated mutation in the PI3K gene, whereas one-third of the patients demonstrated CNV in the KIT gene. Thus, administration of the PI3K and KIT gene inhibitor drugs might be proposed to suppress breast cancer in patients with mutation and CNV of each of these individual genes.
Abedin Saghafipour, Ahmad Mousazadeh-Mojarrad, Niloofar Arzamani, Zakyeh Telmadarraiy, Rezvan Rajabzadeh, Kourosh Arzamani,
Volume 33, Issue 1 (2-2019)
Abstract
Background: Crimean-Congo hemorrhagic fever (CCHF) is a prevalent tick-borne disease in different regions of Iran. This molecular and serologic study was performed to investigate the Crimean-Congo hemorrhagic fever virus (CCHFV) in collected ticks and in blood samples of some domestic animals in North Khorasan, Northeast of Iran.
Methods: In this cross sectional study, 136 blood samples from domestic animals (sheep, goats, and cows) collected in the Northeast region in Iran were examined using IgG ELISA assay. Ticks (n = 1478) were collected from sheep, goats, and cows. Out of all collected ticks, 62 specimens were investigated for CCHF virus genome using RT-PCR technique. The data were descriptively presented by median and 95% confidence interval (CI).
Results: CCHFV infection rate was 8.1% in studied ticks. Two species of ticks, Hy. anatolicum (n=3; 15%, 95% CI 9.41–20.59) and Rh. sanguineus (n=2; 6.9%, 95%CI 4.33–8.58), were infected with CCHFV genome and were probable vectors of CCHF virus in the area. Infection rate was 15.4% for CCHFV in tested domestic animals. Serologic tests detected CCHFV specific IgG antibodies in 16.2% (95% CI 13.49–18.83) (99/16) and 19.2% (95% CI 13.26–25.20) (26/5) of sheep and goats, respectively.
Conclusion: The present study showed that domestic animals and ticks were infected with Crimean-Congo hemorrhagic fever virus and that the disease was endemic in North Khorasan province, Iran. However, further surveillance and prevention programs are recommended.
Morteza Hemmat, Haleh Ayatollahi, Mohammadreza Maleki, Fatemeh Saghafi,
Volume 33, Issue 1 (2-2019)
Abstract
Background: Health information technologies (HIT) have some benefits and may have some potentially negative impacts. Therefore, it is difficult to plan for future health information technologies. This study aimed to investigate the key and non-key health information technologies which could be considered for the future strategy development in Iran.
Methods: In this study, experts and policymakers in the field of health information technology were invited to take part in a qualitative study. Purposive sampling was used to select the most informant people, and 13 interviews were conducted. The method of framework analysis was used to analyze data.
Results: The four main themes emerged from data analysis were 1) immediate, cheap, stable, and secure access to the health records of the society, 2) equitable access to health care resources and services, 3) knowledge management in healthcare services, and 4) governmental/central electronic services for the health system. To cover the mentioned areas, a number of key and non-key technologies were discussed by the interviewees.
Conclusion: In this study, a number of key and non-key health information technologies were recognized. While the findings can help policymakers to pay more attention to the key technologies to improve healthcare delivery, these technologies need to be prioritized in terms of their importance for the country.
Mahsa Babaei, Saeid Rezaei, Shadi Saghafi Khadem, Iman Shirinbak, Samira Basir Shabestari,
Volume 36, Issue 1 (1-2022)
Abstract
Background: Blood sampling is expensive, time-consuming, invasive, and requires technical facilities, which can be replaced by more convenient samples such as saliva. C-reactive protein (CRP) is a widely used biomarker in the management of many disorders and plasma CRP (pCRP) is suggested to be replaced by salivary CRP (sCRP). This study aimed to systematically review all available literature on the sCRP levels in systemic and oral disorders and how sCRP and pCRP levels correlate among these patients and healthy individuals.
Methods: In this systematic review, a PubMed, Embase, Scopus, and Google Scholar search was conducted on October-2021 to identify all research investigating sCRP levels in systemic and oral disorders.
Results: A total of 130 publications were analyzed in the review. Most of the studies reported that sCRP and pCRP levels are correlated, and sCRP is a reliable alternative for pCRP level for the diagnosis and management of medical conditions. sCRP has been measured in many different medical and oral disorders and significantly correlated with disease activity in most cases.
Conclusion: Salivary CRP is a good alternative for Plasma CRP levels in most cases.
Ladan Haghighi, Maryam Rahimi, Behnaz Mohabatian, Zahra Rampisheh, Mahshid Shirvani, Samaneh Saghafian Larijani,
Volume 37, Issue 1 (2-2023)
Abstract
Background: This study aimed to compare sublingual misoprostol alone or combined with vaginal Isoniazid (INH) for first-trimester abortion.
Methods: In this randomized controlled trial, 80 pregnant women with missed abortion candidates for first-trimester abortion were randomly assigned to two groups. The first group received 800 μg sublingual misoprostol every three hours maximum for three doses and the second group received 1500 mg vaginal INH followed by the same dose of misoprostol. Vaginal sonography was performed after 24 hours on both groups to observe any retained product of conception. In case of no response or incomplete abortion, the second course of misoprostol (with the same dose) was administered. The abortion (complete or incomplete) rate was reported within 48 hours after the first dose of misoprostol.
Results: The rate of successful intervention (either complete or incomplete) abortion within 48 hours of misoprostol administration was 75% in both groups and was not significantly different (P value = 1). Also, hospitalization duration, abortion time, total misoprostol dosage, and the rate of side effects were similar in the two groups. Five patients in the misoprostol group and three in the misoprostol plus isoniazid group underwent emergent D&C because of heavy bleeding.
Conclusion: A combined regimen of sublingual Misoprostol plus vaginal Isoniazid with the prescribed dosage has similar efficacy to sublingual misoprostol alone in first-trimester abortion.
