Showing 39 results for Shadi
H Hodjati, S Arshadi,
Volume 11, Issue 1 (5-1997)
Abstract
Hepatic artery aneurysms are a rare cause of upper gastrointestinal hemorrhage
and may represent significant problems in both diagnosis and management. We
report a 70 year old patient with gastrointestinal bleeding from a fistula between
a 7 cm hepatic artery aneurysm and the duodenum. He underwent successful
surgical management with endoaneurysmorrhaphy and duodenal wall repair.
M Saberi-Firouzi, F Kaffashian, E Hayati, Aa Ghaderi, H Keshavarz, S Arshadi, C Arshadi, Mse Sotudehmaram, Ms Massarrat, Ma Ghalambor,
Volume 12, Issue 2 (8-1998)
Abstract
In order to assess the prevalence of Echinococcus granulosus (EO) infection
(hydatidosis) in nomadic tribes of southern Iran, 1000 individuals from a total
population of 1 12,519 were selected by randomized single blind cluster sampling
method and studied from 1994- 1995. The study included: ( l ) a physical
examination by a gastroenterologist, (2) abdominal ultrasonography (US), and
(3) detection of anti-EO-antibodies (EOA) by an enzyme-linked immunosorbent
assay (ELISA) and counterimmunoelectrophoresis (CIE). The statistically
significant prevalences were: US: 1.8%, eIE: 6.8%, and ELISA, 13.7%. The
rate of infection varied with age, sex, education, occupation, life style,
geographical location of tribal subgroups and the frequency of contact with dogs
and cattle. The power of agreement between a combination of each two methods
were significant as determined by kappa statistics method. The results obtained
indicated that a combination of ELISA and CIE was the most reliable method
with a high sensitivity and specificity.
Mr Yaghoobi-Ershadi, Aa Akhavan, M Mohebali,
Volume 15, Issue 3 (11-2001)
Abstract
Following an epidemiological survey of zoonotic cutaneous leishmaniosis
(ZCL) in some villages of Badrood, a rural district north of the city of Natanz,
central Iran, Phlebotomus (Phlebotomus ) papatasi Scopoli were found to be naturally
infected with Leishmania (Leishmania) major zymodeme MON-26. Sandflies
were collected and dissected biweekly from rodent burrows during sandfly season,
April- October 1998. Leptomonad infection rates varied between 6.7-22.0%
during sandfly season, being greatest in September, coinciding with peak activity
of P papatasi, 2-3 months before the highest incidence of ZCL human cases in
November-December. Leptomonad infection rate was 1.1 % in 94 P papatasi
indoors.
M Mohebali, Mh Motazedian, F Parsa, H Hajjaran, Mr Yaghoobi-Ershadi,
Volume 15, Issue 4 (2-2002)
Abstract
In this study, we used Random Amplified Polymorphic DNA (RAPD) for
identification of 17 isolates of Leishmania from the skin and reticuloendothelial
system of humans, animal reservoirs (rodent and dog) and sandflies in various
parts of Iran in the last decade.
Fifteen species have been confirmed by isoenzyme characterization by the
London School of Hygiene and Tropical Medicine and Shiraz University of Medical
Sciences. In this study, strong confirmation has been observed between random
amplified polymorphic DNA with isoenzyme characterization.
Roozbeh Naghshin, Fatemeh Yahyapour, Pejman Zoroufchian Moghaddam, Shadi Ghourchian,
Volume 25, Issue 1 (5-2011)
Abstract
Abstract
Mammary tissue, skeletal muscle, and spleen are less frequently affected by mycobacterium tuberculosis (TB).
The most common age for breast TB is between 50 and 70. On this article, we are reporting a 72-year-old woman
who presented with chronic cough, lobar consolidation in right middle lobe (RML) on the CXR, and a mass
in her right breast revealed on the physical examination. Biopsy from the breast lesion showed granulomatous
changes and acid fast bacilli were detected by bronchoalveolar lavage. Treatment for TB was begun and the
patient showed significant improvement.
Based on the patient’s age, breast carcinoma was suspected first. Sinus formation was found on her breast ultrasound.
This is a common finding and not diagnostic for TB. Our report is a reminder that although breast
masses in older women tend to be more malignant, tuberculosis should be considered in differential diagnosis,
especially in postmenopausal women. Moreover, breast TB can present with insidious growth without any
symptoms.
Najmosadat Atefi, Mahboobeh Rahimi, Shadi Peyghambari, Shadi Ghourchian,
Volume 25, Issue 4 (12-2011)
Abstract
Abstract
Background: Chronic urticaria (CU) is a common dermatological disease that induces a substantial burden on individuals’ life. Also if one’s self-image changes (which usually happen in patients with dermatological diseases), it leads to anxiety or other various symptoms. We aimed to compare the psychological scales in patients with CU with non-dermatological individuals with the purpose of early diagnosis and appropriate psychiatric consult.
Methods: In this study, psychological status of 30 patients with the diagnosis of chronic urticaria (lasting for more than 6 weeks) and 30 controls, chosen among the hospital staff were evaluated. Evaluation was carried out by using standard General Health Questionnaire (GHQ-28). Psychosomatic disorders, anxiety, depression and social functions were assessed. Data were analyzed by SPSS version 16, and the frequency indices and Chi- Square test.
Results: Although from 30 patients with CU, 63.3% suffered from psychological disorders, this prevalence was estimated 46.6% in the control group. Altogether, psychological disorders in patients with CU were significantly (p=0.007) more prevalent than individuals without dermatological problems. Anxiety was the most common reported disorder.
Conclusion: In our study, the most prevalent psychiatric disorders included anxiety, psychosomatic disorders, social dysfunction and depression, sequentially. It seems that depression is the least significant psychiatric disorder among patients who suffer from urticaria. Also, anxiety was the most reported disorder among them, which may be considered as the primary cause of the disease or it may be secondary to the disease process. This theory clarifies the importance of dermatologists and psychiatrists cooperation.
Najmosadat Atefi, Mehrdad Majedi, Shadi Peyghambari, Shadi Ghourchian,
Volume 26, Issue 1 (2-2012)
Abstract
Background: The relationship between Lichen Planus (LP) and diabetes was studied previously, but the re-sults were in conflict. The aim of this study was to find the prevalence of diabetes mellitus (DM) in patients with LP among Iranian patients.
Methods: In this study, 80 patients with LP were enrolled. They referred to dermatology clinic of our hospital during one year. A self-designed checklist for the study included duration of the disease, the pattern of the dis-tribution of lichenoid lesions and fasting blood sugar (FBS).
Results: From 80 patients with LP, 16 (20%) had diabetes. Also, 14 patients (17.5%) had impaired fasting glucose. The mean age of diabetic patients was significantly higher than non-diabetic group (p=0.039). In addi-tion, the duration of LP in patients with DM was significantly higher than non-diabetic patients (p=0.024).
Conclusion: In our study, we saw a high prevalence of DM among patients with LP. Comparing our findings with the overall prevalence of DM in Iran, there was a significant difference between the prevalence of DM among patients with LP and the overall prevalence (p=0.001). Regarding our findings screening for FBS in pa-tients with LP is required in Iran.
Shadi Ghourchian, Babak Zamani, Kosar Poorkosary, Seyed Kazem Malakouti, Mohammad Rohani,
Volume 28, Issue 1 (1-2014)
Abstract
Background:
Major depression is a common disorder with great social and individual burdens.
Transcranial sonography (TCS) is a useful and noninvasive measure for
assessment of normal and impaired brain parenchyma. The brainstem raphe nuclei
are in close association with dorsocaudal limbic system and plays an important role
in depression. In this study we compared the echogenicity of the raphe nuclei
in patients with major depressive disorder and the control group.
Methods:
Thirty patients suffering from depression, diagnosed by a psychiatrist, and
30 cases of similar age and sex were entered into the case and control groups
respectively. Semi-structural clinical conversation was done according to the
DSM IV-TR in order to confirm the depression by the psychiatrist member of the
group. Echogenicity of the brainstem raphe nuclei was assessed by a trained
neurologist using TCS. To compare the mean echogenicity between the two groups
independent sample t-test was used. In order to assess the strength of association
between the disease and the echogenicity, odds ratio was also calculated.
Results:
The echogenicity of the brainstem raphe nuclei was significantly decreased in
depressed patients (36.7%) in comparison with the control group (10% ) (p=
0.015, OR= 5.21).
Conclusion:
Echogenicity of the brainstem raphe nuclei in patients with depression is
significantly lower than normal population. To confirm the results, we
recommend a meta analysis considering previous articles' results.
Majid Naderi, Shadi Tabibian, Akbar Dorgalaleh, Zahra Kashani Kahtib, Shaban Alizadeh,
Volume 28, Issue 1 (1-2014)
Abstract
Sima Nedjat, Saharnaz Nedjat, Reza Majdzadeh, Mojgan Farshadi,
Volume 28, Issue 1 (1-2014)
Abstract
Background :People are increasingly interested in health news. As a mass media, the ‘Islamic Republic of Iran Broadcasting’ (IRIB) has the highest number of target audiences. In Iran, some people follow health news via health programs on satellites and other means of communication. However, all of these programs do not live up to the standards of scientific evidence. In this study, we examined Tehran people’s trust in health news disseminated by the IRIB and other mass media outlets.
Methods :A cross-sectional study was conducted in Tehran. Through multistage sampling, 510 households proportional to size were randomly selected from five regions of Tehran including northern, eastern, western, southern and central regions. One person from each household completed the questionnaire through interviews. The questionnaire included questions on people’s level of trust in health news delivered by the IRIB, satellite programs, the internet and magazines. It also included demographic questions. The validity and reliability of the questionnaire was evaluated.
Results : Among the interviewees, 50.6% was female. The highest level of trust by the participants was observed in the IRIB (65.2%), and the lowest trust was observed in satellite news (43.4%) p<0.001. The interviewees believed that the IRIB news broadcasters had more mastery over the subject than the ones in satellite channels (p< 0.001). The IRIB’s coverage of important and relevant health topics was also significantly perceived to be better than that of satellite news (p< 0.001). According to 83.5% of interviewees, the quality of health news had improved in the past 10 years. Fifty nine point eight percent of participants believed the quality and accuracy of the IRIB health news was monitored.
Conclusion : People’s higher level of trust in domestic news as compared to foreign sources and the better status of domestic sources in other areas such as precision in reporting, coverage of more important news, its delivery in lay language, the news broadcasters’ proficiency, and other cases - from the participants’ point of view - can highlight the significance of designing interventions for changing health behavior among domestic health news producers. Therefore, the results of this study can prove useful to health news policy makers in the IRIB.
Mansoureh Akouchekian, Simin Hemati, Davood Jafari, Nazanin Jalilian, Masoumeh Dehghan Manshadi,
Volume 30, Issue 1 (1-2016)
Abstract
Background: Li-Fraumeni syndrome (LFS) is one of the most serious hereditary cancer syndromes with a high risk of malignancy in childhood. This syndrome is an autosomal dominant cancer predisposing syndrome due to a germline mutation in the TP53 tumor suppressor gene.
Methods: In this study, a representative family case of Li-Fraumeni syndrome is described. The proband of this family was a 43-year-old male who had osteosarcoma of the mandible and a positive family history of cancer. His mother died at the age of 29 of brain cancer; his sister died at the age of 18 of breast cancer; his brother died at the age of 36 of liver cancer; and another sister of his died at the age of 16 of leukemia. Complete sequence analysis of the TP53 and PTEN genes was performed in this family. We used standard diagnostic tools such as sequencing and multiplex ligation-dependent probe amplification (MLPA) to analyze these two genes in this family. The exons and flanking exon-intron junctions of the TP53 and PTEN genes were sequenced.
Results: We detected a germline mutation in the TP53 gene in this family that was previously reported as somatic mutation in LFS in the catalogue of somatic mutations in cancer (COSMIC). In addition, according to the International Agency for Research of Cancer (IARC) database, a 19-year-old male patient with sarcoma was recently reported to have this germline mutation. We also found two new IVS variations in the PTEN gene, one of which can be a suggestive evidence of an effect on the splicing of PTEN.
Conclusion: Genomic modifications for tumor risk and genotype-phenotype correlations in LFS are still to be identified. We believe every new finding in this area can provide new insights into the pathogenesis and progression of Li-Fraumeni syndrome.
Silva Hovsepian, Roya Kelishadi, Mohammad Esmaeil Motlagh, Amir Kasaeian, Gita Shafiee, Tahereh Arefirad, Fereshteh Najafi, Maliheh Khoramdad, Hamid Asayesh, Ramin Heshmat, Mostafa Qorbani,
Volume 30, Issue 1 (1-2016)
Abstract
Background: There are few epidemiological reports on adherence to physical activity (PA) and screen-time (ST) recommendations among Iranian children and adolescents at the provincial level. We used nationally representative data to provide recent prevalence estimates of Iranian children who met the recommendations for PA and ST.
Methods: This nationwide study was conducted among 14,880 students aged 6-18 years from 30 provinces of Iran. The frequency of the recommended level for PA (>1 hours/week) and ST (<2 hours/day) and different combinations of PA and ST was determined in the studied population.
Results: In this study, 13,486 students (response rate: 90.6%) were studied. Overall, 18.62%, 34.11%, 50.66% and 9.63% of the students reported high ST, low level of PA, high TV watching and high computer working, respectively. The frequency of the recommended level of PA and ST was 53.92%. Of the studied population, 6.63% had low PA and high ST. Paradox combinations of low PA and low ST and moderate/high PA and high ST was prevalent among 27.47% and 6.26% of the children and adolescents. The lowest and highest frequency of recommended level of PA and ST was 38.9% and 65%, respectively. The lowest and highest frequency of low PA and high ST was 1.87% and 13.77%, respectively.
Conclusion: The results of this study revealed that the frequency of low PA was high and that approximately 46% of the students did not meet the recommended level of PA and ST. The findings indicated that preparing facilities for improving PA level among children should be the main priority in our future interventions in this field.
Parisa Mirmoghtadaee, Ramin Heshmat, Shirin Djalalinia, Nazgol Motamed-Gorji, Mohammad Esmaeil Motlagh, Gelayol Ardalan, Saeid Safiri, Zeinab Ahadi, Gita Shafiee, Hamid Asayesh, Mostafa Qorbani, Omid Yaghini, Roya Kelishadi,
Volume 30, Issue 1 (1-2016)
Abstract
Background: Socioeconomic status (SES) is a major determinant of health inequality in children and adolescents. The aim of this study was to evaluate the association of SES of family and living region with self-rated health (SRH) and life satisfaction (LS) among children and adolescents.
Methods: This study was a part of the fourth survey of a national surveillance program, which was conducted in 30 provinces of Iran in 2011-2012. LS and SRH were assessed by a questionnaire based on the World Health Organization-Global School-based student Health Survey (WHO-GSHS). Family SES was estimated using principal component analysis (PCA) and based on family assets, parental education and occupation, and type of school. Region SES was calculated using PCA and some variables including literacy rate, family assets and employment rate.
Results: Out of 14,880 invited students, 13,486 (participation rate: 90.6%) completed the survey; of whom, 49.2% were girls, and 75.6% were from urban areas with the mean ± SD age of 12.47±3.36 years. In the multivariate model, SES of family and living region was associated with LS and good SRH. In the full models, in addition to all potential confounders, family and living region SES were included simultaneously. However, only the association of family SES with LS, and good SRH remained statistically significant.
Conclusion: The effect of families’ SES on SRH and LS is more important than regional SES. The presented patterns of SRH and LS may be useful in developing better health policies and conducting complementary studies in this field.
Roya Kelishadi, Arash Rashidian, Mohsen Jari, Ardeshir Khosravi, Roghayeh Khabiri, Elham Elahi, Maryam Bahreynian,
Volume 30, Issue 1 (1-2016)
Abstract
Background: Breastfeeding has been recognized to have a great deal of benefits for both the mothers and infants. Moreover, the importance of exclusive breastfeeding in the first six months of life has been greatly acknowledged. Therefore, this study aimed to determine the prevalence of starting breastfeeding in the first hour after delivery and the exclusive breast milk feeding as well as the age at which complimentary foods are provided to the child and duration of breastfeeding in Iran.
Methods: This nationwide cross-sectional study was conducted in the frame of a national survey, Iran Multiple Indicator Demographic and Health Survey (IrMIDHS), in 31 provinces of Iran. Participants were selected by multistage cluster sampling. The target sample was 3,096 clusters consisting of 2,187 urban and 909 rural families. Data were collected using a questionnaire through face-to-face interviews.
Results: The rate of exclusive breastfeeding was 53.13% with higher prevalence in rural (67.76%) than in urban areas (47.79%) (P = 0.04), and among girls (56.35%) compared to boys (50.60%). The prevalence of breastfeeding as the main diet of Iranian infants under six months old was 70.72% and the prevalence of initiation of breastfeeding (up to the first hour after delivery) was 68.70%. The probability of breastfeeding continuance among twelve to fifteen months children was 84.22%; the corresponding figure was 51% among twenty to twenty three months old babies (p=0.03).
Conclusion: Exclusive breastfeeding should be encouraged; and strategies that are more effective should be designed to protect, train and support young mothers to breastfeed their infants. The importance of early beginning of breastfeeding and its continuation should be underscored.
Nasser Mostafavi, Moein Bighamian, Sina Mobasherizade, Roya Kelishadi,
Volume 30, Issue 1 (1-2016)
Abstract
Background: The aim of this study was to determine the serotypes and antimicrobial susceptibility of Shigella spp. in Isfahan, (Iran) from 2010 to 2015.
Methods: This retrospective study was conducted on Shigella isolates in four tertiary care hospitals. The process of bacterial isolation and determination of susceptibility was performed by standard microbiological guidelines. The patients were categorized into three age groups of under 5, 5-15 and over 15 years.
Results: Among 45 isolates, S. sonnei (63.6%) was the predominant species, followed by S. flexneri (34.1%), and S. dysenteriae (2.3%). Substantial resistance to ampicillin, trimethoprim- sulfamethoxazole, ceftriaxone, cefotaxime, and cefixime was observed. Over 94% of the isolates were sensitive to ciprofloxacin. Susceptibility of isolates was similar between all age groups.
Conclusion: Significant resistance to third generation cephalosporins precludes the use of these agents for empirical treatment of shigellosis in our population. Ciprofloxacin is an appropriate option; however, susceptibility tests should be performed before prescription.
Mahin Hashemipour, Maryam Kargar, Alireza Ghannadi, Roya Kelishadi,
Volume 30, Issue 1 (1-2016)
Abstract
Background: Childhood obesity is becoming a global problem and its incidence is increasing. The role of dietary intervention with fruits containing vitamin C and flavonoid to control obesity consequences in childhood has not been yet defined. Lemon (Citrus aurantifolia) peels contain flavonoid, pectin and vitamin C. We aimed to compare the effects of lemon peels and placebo on cardiometabolic risk factors and markers of endothelial function among adolescents with overweight and obesity.
Methods: In this triple-masked, randomized controlled trial, 60 overweight/obese adolescents were enrolled in a 4-week trial. Eligible participants were randomly assigned into two groups of equal number receiving daily oral capsules containing lemon powder or placebo. Fasting blood sugar, lipid profile, ICAM-1 and VCAM-1, as well as systolic and diastolic blood pressure were compared between the two groups before and after administration of medication and placebo.
Results: Of the total 60 enrolled patients, 30 and 29 patients in the lemon and control groups completed the study, respectively. The results of within-group analysis demonstrated a slight reduction in body mass index, LDL-C and systolic blood pressure in the lemon group, but no between group differences existed in the studied variables.
Conclusion: This study revealed that consumption of lemon peel extract has some beneficial effects for childhood obesity; however, no considerable effect was documented on anthropometric measures and biochemical factors. Future studies with longer follow up are highly recommended.
Behzad Shams, Elnaz Afshari, Mohammadhasan Tajadini, Mojtaba Keikha, Mostafa Qorbani, Ramin Heshmat, Mohammad Esmaeil Motlagh, Roya Kelishadi,
Volume 30, Issue 1 (1-2016)
Abstract
Background: Vitamin D (VitD) deficiency is a common worldwide problem. Some previous studies have shown that both Zinc (Zn) and VitD deficiency are prevalent in Iran. This study aimed to assess the relationship of serum Zn and vitamin D levels in a nationally representative sample of Iranian children and adolescents.
Methods: This case-control study was conducted as a sub-study of a school-based surveillance program entitled “the CASPIAN-III Study”. An equal number of individuals with and without hypovitaminosis D including 330 participants aged 10 to 18 years were selected. The correlation of serum 25 hydroxy vitamin D (25(OH) D), cardiometabolic factors and Zn concentrations was determined. Statistical analysis was done using one-way analysis of variance (ANOVA), Pearson's correlation, linear regression, and logistic regression.
Results: The mean age was not significantly different in participants with and without hypovitaminosis D (14.74±2.52 vs. 14.74±2.66 years, respectively, p>0.05). The mean 25(OH) D level was 6.34±1.47ng/ml in the group with hypovitaminosis D and 39.27±6.42ng/ml in controls. The mean Zn level was significantly lower in the hypovitaminosis D group than in controls (1.15±0.26 vs. 1.43±0.32µg/ml, respectively, p<0.001). The Pearson's analysis showed a positive and significant correlation between Zn and 25(OH) D serum levels (p<0.0001). Odds ratios analysis for VitD level between various quartiles of serum zinc concentration for all participants showed that the odds of higher levels of VitD increased by higher levels of Zn.
Conclusion: We found significant associations between low serum concentrations of zinc and 25(OH) D. Food fortification or mineral supplementation should be considered in future health programs.
Mostafa Qorbani, Roya Kelishadi, Shirin Djalalinia, Mohammad Esmaeil Motlagh, Amir Kasaeian, Gelayol Ardalan, Gita Shafiee, Omid Safari, Ramin Heshmat, Sadegh Baradaran Mahdavi,
Volume 30, Issue 1 (1-2016)
Abstract
Background: This study aimed to assess the pattern of hygienic behaviors of Iranian children and adolescents at national and sub-national levels according to the socioeconomic status (SES) of their living region.
Methods: Data were obtained from the fourth national school-based surveillance survey entitled, “CASPIAN-IV study” (2011-2012). It was conducted among 14,880 students, aged 6-18 years, who were selected by multistage random cluster sampling from 30 provinces in Iran. We used the World Health Organization Global School-based Student Health Survey (WHO- GSHS) questionnaire. Data were analyzed at national and sub-national levels according to the SES of the living region.
Results: Overall, 13,486 students (49.2% girls) with the mean (SD) age of 12.50 (3.36) years participated in this study (participation rate: 90.6%). At the national level, 67.21% of the participants had daily tooth brushing, the frequencies for always washing hands after using the toilet, washing hands before eating, and washing hands with soap in school were 85.61%, 56.53%, and 50.32%, respectively.
The frequency of daily tooth brushing had no significant difference according to the SES of the living region. In all of the categories of washing hands, the West region (second high SES rank) had the highest frequency of hygienic behaviors (p<0.001).
Conclusion: In general, the reported hygienic behaviors were at an acceptable level; however, a large comprehensive health-promoting plan should be considered for all children and adolescents at the national and sub-national levels taking into account the disparities according to their SES.
Ghobad Moradi, Hossein Safari, Bakhtiar Piroozi, Laila Qanbari, Salahadin Farshadi, Homan Qasri, Fariba Farhadifar,
Volume 31, Issue 1 (1-2017)
Abstract
Background: One of the main goals of health systems is to protect people against financial risks associated with diseases that can be catastrophic for patients. In 2014, Health Sector Evolution Plan (HSEP) was implemented in Iran; one of the objectives of HSEP was to reduce out-of-pocket payments and provide more financial protection for people. Therefore, the present study aimed at exploring the likelihood of facing catastrophic health expenditures (CHE) among households with members suffering from dialysis, kidney transplant, or multiple sclerosis (MS) after the implementation of HSEP.
Methods: A total number of 385 households were selected using stratified random sampling and were asked to complete the World Health Survey questionnaire through telephone conversations. As outlined by the World Health Organization (WHO), when household out-of-pocket expense for health services is ≥40% of its capacity to pay, then that household is considered to be facing CHE. Furthermore, determinants of CHE were identified using logistic regression.
Results: The percentage of facing catastrophic health care expenditures for households with a MS, dialysis, and kidney transplant patient was 20.6%, 18.7%, and 13.8%, respectively. Results of logistic regression analysis revealed that patient’s economic status, level of education, supplementary insurance status, type of disease, multiple members with special diseases in the household, rural residence, use of inpatient, dental, and rehabilitation services were effective factors for determining the likelihood of facing CHE.
Conclusion: Despite the implementation of HSEP, the percentage of CHE is still high for households that have members who suffer from special diseases. However, basic health insurance packages should be amended and more cost-sharing exemptions should be granted to provide more financial protection for the vulnerable households.
Sedigheh Saedi, Mona Noroozi, Naghmeh Khosrotabar, Shadi Mazandarani, Behshid Ghadrdoost,
Volume 31, Issue 1 (1-2017)
Abstract
Background: Restricted intakes of saturated and trans-fatty acids and replacement with poly or monounsaturated fatty acids are
emphasized in healthy diets. This study evaluates the effects of a six-month consumption of canola oil compared to sunflower oil on
lipid profile and anthropometric parameters of people affected by dyslipidemia.
Methods: This randomized controlled trial was conducted on 96 patients with dyslipidemia, who were randomly assigned into canola
oil or the sunflower oil groups. The participants were instructed to record the contents of their daily meals, beverages, fruits, and
snacks a day before treatment, at the second clinic visit, in the third month, and at the end of study (i.e., six months). Lipid profile and
anthropometric parameters were compared between the two groups. Student t-test or Mann Whitney U test was used for statistical
comparisons of variables between groups. Multivariate analysis was performed to adjust the confounding factor effects.
Results: Of the enrolled participants, 44 (45.8%) were on sunflower oil diet and 52 (54.2%) on canola oil diet. We observed no
change in anthropometric parameters and thus no significant difference between the two groups (p>0.05). Significant reductions in
LDL-C (p<0.001), total cholesterol (p<0.001) and triglyceride levels (p<0.001), and significant elevation in HDL-C (p=0.008) were
observed in canola oil group, as well as those who used sunflower oil.
Conclusion: Dietary fats in the form of canola oil or sunflower oil effectively lower the serum cholesterol, LDL-C and triglyceride
concentrations. They also result in an increase in serum concentration of HDL-C. These oils, however, did not modify general anthropometric
parameters.
