A A. ebrahimi Nejad, A Zaree,
Volume 14, Issue 2 (8-2000)
Abstract
Hepatoblastoma (HB) is a rare tumor of infancy and childhood manifesting
with hepatomegaly and abdominal distention. It is seen with increased frequency
in association with congenital hemihypertrophy and renal anomalies. Metastases
to other organs, including the lungs, lymph nodes and even ovaries is well known.
But cerebral metastasis of this tumor, especially in the absence of metastasis to
other organs, has not yet been reported. In this paper a 3-year old male child with
congenital hemihypertrophy and isolated metastasis of HB to the brain is presented.
Farzane Rezaei Yazdi, Aziz Ghahary, Mohammad Mirdoraghi, Hamzeh Sarvnaz, Mohammad Hossein Asgardoon, Tayebeh Rastegar, Fatemeh Malek, Tahereh Abbasi Moayyer, Kamyar Ghaffari Dafchahi, Nasrin Takzaree,
Volume 35, Issue 1 (1-2021)
Abstract
Background: The burn wound is one of the health problems in the world that affects physical and mental health. Today, adipose-derived mesenchymal stem cells (ADSCs) have received medical attention for their accessibility and the ability to reproduce and repair. The present study was designed to investigate the effect of ADSCs on burn wound healing.
Methods: The present experimental study was performed on 36 male Wistar rats divided into 1 control group and 3 experimental groups. The second-degree burns with a radius of 10 mm were induced after anesthesia. ADSCs and Dulbecco's Modified Eagle Medium (DMEM) were injected into the dermis around the burn area in the ADSCs and DMEM groups, respectively. Silver sulfadiazine (SSD) ointment was applied topically once daily as the SSD group. The control group did not receive any treatment. The rats were evaluated for 21 days. Wound healing rate, histopathological parameters, and the number of fibroblasts were evaluated by the immunofluorescence technique and vascular endothelial growth factor and transforming growth factor β (TGF-β) gene expression by reverse transcription-polymerase chain reaction. The results were entered into SPSS software (SPSS Inc) and analyzed with 1-way analysis of variance and repeated measures analysis.
Results: The number of fibroblasts, the number of vessels, TGF-β, and VEGF gene expression in the burn area were significantly higher in the ADSCs group than in the SSD, DMEM, and control groups. The results also showed that the amount of inflammation was significantly lower in the ADSCs group compared with the control group (p<0.001). Moreover, the percentage of wound recovery was significantly higher in the ADSCs group compared with other groups (p<0.001).
Conclusion: ADSCs accelerate and improve burn wound healing by affecting fibroblasts, keratinocytes, and inflammatory cells as well as increasing the expression of the TGF-β and VEGF genes, and thus increase in angiogenesis.
