Showing 1 results for Amygdala-Kindled Rats.
M Sayyah, Mh Pourgholami,
Volume 12, Issue 4 (2-1999)
Abstract
The effect of intracerebroventricular administration of progesterone and its
metabolite allopregnanolone(3a-hydroxy-5a-pregnane-20-one)on the amygdala
kindling model of seizures was studied in male rats. Neither progesterone (10, 50,
200 g/rat) nor allopregnanolone (12.5, 50, 100 µg/rat) had any effect on seizure
parameters at 5, 15 and 30 min. after administration. Although previous studies
imply the anticonvulsanteffect of progesterone and its metabolite allopregnanolone
against seizures induced by GABAA receptor antagonists, the present data do not
support the anticonvulsant activity of these two steroids in amygdala-kindled
seizures.
