Abbas A. Ghaderi, Mh Agahi, Z Amirghofran, S Ardehali,
Volume 9, Issue 3 (10-1995)
Abstract
Two IgM monoclonal antibodies (MAb) with strong reactivity for granulocytes
and to a lesser extent for lurkat cell lines were established by immunizing BALBI
c mice with a histiocytic cell line (UY37). These two MAbs (designated as 6C9 and
4C4) reacted with blast cells of T-acute lymphoblastic leukemia (T-ALL) and
acute myelogenous leukemia (AML) patients as well as leukemic cells from
patients known as unclassified leukemia (UL). According to their pattern of
reactivity, it is most probable that these two IgM MAbs react with some highly
glycosylated membrane determinants such as 3-fucosyl-N-acetyllactosamine (3-
FAL) which are exclusively expressed on some subsets of granulocytes and AML
cells.
