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CRUSH PREPARATION CYTOLOGIC FINDINGS OF CNS TUMORS: A STUDY OF 199 CASES
Perikala V. Kumar, A Monabbati,
Volume 12, Issue 2 (8-1998)
Abstract
Crush preparation cytology technique was used during the operative procedure for the diagnosis of 199 CNS tumors. This technique is simple, easy to perform, rapid, and inexpensive. The cytomorphologic findings were excellent and helped achieve a rapid and correct diagnosis. This technique was used on the tiny, small specimens which were not suitable for frozen sectioning. The results were compared with biopsy reports. The overall diagnostic accuracy by this technique was about 97.7 %.
Frequency of neurological involvement in patients with/without diarrhea hemolytic uremic syndrome: A Systematic review and meta-analysis
Azita Tavasoli, Shahrbanoo Nakhaiee, Nazanin Zafaranloo, Rozita Hoseini, Hasan Otukesh, Behnam Sobouti,
Volume 35, Issue 1 (1-2021)
Abstract
Background: Diarrhea-associated-hemolytic-uremic-syndrome (D+HUS) is a common from of HUS. Central-nervous-system (CNS) involvement is one of the most common extrarenal organ involvements in children with D+HUS. This systematic review and meta-analysis aim to recognize the frequency of neurological complications in pts with HUS.
   Methods: Databases of PubMed, Embase, and Web of Science were searched systematically to find the papers on neurological involvement in HUS pts. Two researchers independently assessed the papers’ quality and extracted data. CMA v. 2.2.064. was used for data analysis. Heterogeneity was evaluated using the I-squared (I2) test, and a fixed/random-effects model was used when appropriate.
   Results: In this review, 21 studies including 2,189 participants with a median age between 1.3-40-year-old, entered the meta-analysis. The meta-analysis in D+HUS patients indicated 27.0% with neurological complications (95% CI, 22.0%-32.6%), 25.5% of symptoms weren’t categorized (95% CI, 15.9%-38.3%), 20.8% of them developed the seizures (95% CI, 2.3%-74.4%). In D-HUS pts, 20.8% of them were presented neurological symptoms (95% CI, 17.9%-24.0%), of which 29.0% weren’t categorized (95% CI, 19.2%-41.2%), 17.5% of pts got into coma (95% CI, 9.6%-29.7%), 5.6 % showed hemiparesis (95% CI, 2.8%-10.9%), 17.2% experienced lethargy (95% CI, 5.2%-44.1%), 30.5% developed the seizures (95% CI, 18.2%-46.2%), 7.4% manifested speech abnormalities (95% CI, 0.2%-7.22%), 6.4% of D-HUS pts presented visual-disturbances (95% CI, 3.4%-11.6%).
   Conclusion: This systematic review and meta-analysis indicated more than one-fourth of both D+HUS and D-HUS patients were presented with neurological symptoms, and the most prevalent symptoms were seizures, which can lead to an epilepsy sequel.
 
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