Showing 3 results for Cutaneous Leishmaniasis
Sima Rafati Seyedi Yazdi, Stephane Couty-Jouve, Mohammad H Alimohamadian, Yahya Dowlati,
Volume 11, Issue 1 (5-1997)
Abstract
This study was performed in order to define the cellular immune response of
12 recovered cutaneous leishmaniasis subjects to different soluble antigens of the
amastigote form of Leishmania major. A soluble leishmanial antigen preparation
(SLA) derived from highly-purified amastigotes from infected nude mice was
fractionated by Mono Q column using Fast Protein Liquid Chromatography
(FPLC) system. Three different fractions were obtained. The lymphoproliferative
response, interferon•gamma (IFN.'Y) and interleukin•4 (JL•4) to amastigote SLA
and its three subfractions were measured. The highest proliferative response and
specific IFN.'Y production without synthesis of fL•4, was induced by the fITst
fraction of amastigote SLA. These results showed that the individuals who had
recovered from cutaneous leishmaniasis had expanded memory T- cell clones
recognizing different antigens in the first fraction of amastigote SLA.
The main and most important point of this study was the identification of one
fraction of an amastigote antigen which preferentially reacted with cells from
recovered human cutaneous leishmaniasis cases.
Jamshid Ayatollahi, Ali Fattahi Bafghi, Seyed Hossein Shahcheraghi,
Volume 28, Issue 1 (1-2014)
Abstract
Cutaneous Leishmaniasis may present with clinical presentation such as zosteriform, sporotrichoid and erysipeloid. The eczema variant has rarely been reported. We report a 27- year- old patient with atypical cutaneous leishmaniasis resembling eczema on the hand of a man in Yazd province in the central of Iran.
Dindar Qurtas,
Volume 32, Issue 1 (2-2018)
Abstract
Background: Cutaneous leishmaniasis (CL) is an infectious disease of zoonotic characteristic; its etiological agent is a protozoan of Leishmania species. This infectious agent is transmitted to humans through a secondary vector, which is infected sand-fly. According to WHO report, Iraq is a country where cutaneous leishmaniasis is an emerging disease, especially, its rural areas are labeled to be the source of the infection and endemicity. Course of the disease and treatment is highly defined by the subtype of cutaneous leishmaniasis and its species.
Methods: Data were collected from cutaneous leishmaniasis registry database of Erbil Dermatology Teaching Center in city of Erbil from August 2016 to August 2017. The collected data were descriptively analyzed for the clinical manifestations and the course of disease in the outbreak of this disease in Erbil governorate.
Results: A total of 124 patients were enrolled in this study. Among them, 93 (75%) were male and 31 (25%) were female. Their age ranged from 2 years to 73 years, with the mean age of 30.7±11.3. The majority of the patients were members of army forces. The total number of the lesions was 325. The number of lesions being ulcerated at the time of presentation was 179 (55%) and non-ulcerated lesions 146 (45%). Time needed for improvement ranged from 1.5 to 4.8 months. Recovery time of cutaneous leishmaniasis lesions from time of onset to the remission ranged from 1.3 to 14.3 months.
Conclusion: The complete recovery time of the CL lesions was longer than what has been mentioned previously in Iraq. Ulceration of the lesions depends on the diameter of the lesions, as increased diameter increases the possibility of the ulceration. The possibility of lesion ulceration increases with an increase in the diameter of the lesions. Considering the observations in different clinical patterns and course of this disease, further studies should be conducted to identify CL species.
