M Mohammadi, Mr Ashrafi, R Shabanian,
Volume 16, Issue 2 (8-2002)
Abstract
To evaluate the changes of ABR values in hyperbilirubinemic newborns, 85
cases with severe jaundice (total bilirubin levels over 16 mg/dL and direct bilirubin
less than 2 mg/dL) were selected from those admitted to Children's Medical
Center by simple sampling method. These infants had no other problem except
jaundice. ABR was taken before treatment in all cases and in some (10 cases)
after exchange transfusion or phototherapy as treatment modalities. 41 neonates
(48%) had abnormal ABR values, such as increased hearing threshold, prolonged
latencies of waves I, III & V (p- value<0.05), prolonged interpeak latencies of I-V
& III-V (p-value<0.05), absence of waves and abnormal wave morphology. These
findings could be indicative of both peripheral (8th nerve) and brainstem disturbances.
After treatment ABRs showed improvement in some aspects, such as
latencies of waves I, III & V (p value<0.05), but not in interpeak latencies (I-III,
III -V & I-V) and hearing thresholds. In accordance with previous studies, there
was no association between serum total bilirubin concentration and ABR test
results. This could be interpreted as low significance of serum total bilirubin as a
criterion for early prediction of bilirubin induced encephalopathy.
