Showing 4 results for Immune System
T Zandieh, F Tarabadi, A Tabatabaiyan, M Izadyar,
Volume 16, Issue 3 (11-2002)
Abstract
The aim of this study was to evaluate the immune system and lymphocyte
function in 41 Iranian β-thalassemic patients and 50 controls, ages ranging
from 2 to 18 years. The patients consisted of 20 splenectomized and 21
non-splenectomized patients. They were treated with Desferal, and had received
repeated blood transfusion. Laboratory investigations included measurement
of total T lymphocytes, active T lymphocytes, B-Iymphocytes and
function of lymphocytes treated with PHA. In this study we observed a significant
reduction of active T lymphocytes and total T lymphocytes in the
patient group compared to controls (p<0.005 & p<0.001), but there was no
significant difference between splenectomized and non-splenectomized patients.
Also in both groups, lymphocyte function was reduced against PHA
(phytohemagglutinin) compared with the controls, and the numbers of B cells
were increased. These results lead to the conclusion that the deficient immune
system in β-thalassemia causes infectious diseases, which finally leads
to death. Therefore, stimulation of the immune system as well as clinical treatment
may prevent infectious disease in patients with β- thalassemia.
Fatemeh Ahmadi, Ataallah Ghadiri, Roohangiz Nashibi, Fatemeh Roozbeh, Reza Alizadeh-Navaei,
Volume 31, Issue 1 (1-2017)
Abstract
Background: Lectin pathway mediates complement activation, which is activated by many microorganisms. This study aimed at determining the serum levels of mannose-binding lectin (MBL) in patients with pulmonary tuberculosis, assessing its relationship to antiuberculosis treatment response, and comparing them with a control group.
Methods: This cross-sectional study was conducted on patients with pulmonary tuberculosis during 2012 and 2013 in South West of Iran. PPD-ST-negative individuals were selected as controls from healthy relatives of patients. Serum MBL levels were measured using ELISA kit (Human MBL HK323, Hycultbiotech Company, Netherlands). All patients were followed- up for response to treatment. We applied Mann-Whitney and Fisher’s exact tests and used SPSS Version 17 software for statistical analysis.
Results: The study included 62 patients as the case group and 63 noninfected TB patients as the control group. The MBL (ng/mL) in patients with pulmonary tuberculosis (median = 1012) was significantly (p= 0.037) higher than that of the control group (median= 296.2). No significant difference was found in the MBL level (ng/mL) between patients with response to antituberculosis treatment (median= 1012) and patients with treatment failure (median= 798.9) (p= 0.84).
Conclusion: MBL may be involved in the pathogenesis of tuberculosis and in the low values that are protective against tuberculosis, and it seems that it has no effect on the antituberculosis treatment response.
Mehrdad Pashazadeh,
Volume 34, Issue 1 (2-2020)
Abstract
Background: Exosomes are extracellular cells (EVs) emancipated by various cell types and are involved in cell-to-cell transmission. In cancer diseases, exosomes emerge as local and systemic cells to cell mediators of oncogenic information and play a significant role in the advancement of cancer through the horizontal transfer of various molecules, such as proteins and miRNAs.
Methods: In this study, 66 articles from PubMed, MEDLINE, Science Direct, Cochrane, EMBASE, and Scopus were used as English sources.
Results: The biological distribution of cancer cell-derived exosomes in tumor tissue is an important factor in detecting their role in tumor increase; on the other hand, a limited number of studies have examined the biodistribution of exosomes in tumor tissues. While exosomes function as cancer biomarkers and support cancer treatment, we have a long way to improve the antitumor treatment of exosomes and develop exosome-based cancer diagnostic and therapeutic strategies.
Conclusion: This review describes the science and significance of cancer pathogenesis and exosomes relative to cancer treatment resistance.
Ali Tootee, Behrouz Nikbin, Ensieh Nasli Esfahani, Babak Arjmand, Hamidreza Aghayan, Mostafa Qorbani, Aziz Ghahari, Bagher Larijani,
Volume 36, Issue 1 (1-2022)
Abstract
Background: In patients with diabetes, transplantation of stem cells increases C-peptide levels and induces insulin independence for some period. Today, this positive therapeutic outcome is widely attributed to the well-documented immunomodulatory properties of stem cells. The aim of this study was to report alternations (the trend of increase or decrease) in different lymphocyte populations in a stem cell clinical trial performed in our institute.
Methods: Recorded data of a clinical trial conducted on 72 patients with type 1 diabetes who had received fetal stem cell transplantation several years ago and were regularly monitored before and after the procedure in 1, 3, 6, 12, 24 months were analyzed. In these regular follow-up visits, insulin demand, HbA1c, C-peptide, and alternation to B cell and T cell populations were analyzed and recorded. For the purpose of the current study, patients were retrospectively divided into 2 groups, namely, those with the positive response to treatment and patients without such response. Temporary positive therapeutic response was defined by 2 different indicators, namely, plasma C-peptide levels and insulin dose-adjusted A1C (IDAA1c), which was calculated as A1C (percent) + (4 × insulin dose (units per kilogram per 24 h). Data analysis was performed by means of SPSS Version 18.
Results: Besides the short-term therapeutic effect, we observed remarkably significant alternations to the populations of B and T lymphocytes in the recipients. When patients were retrospectively assigned to 2 different groups of patients with a positive therapeutic response (based on C-peptide changes) and those without it, it was observed that alternations to different populations of B-cells and T-cells were significantly different in these 2 groups.
Conclusion: Our results demonstrated that transplantation of stem cells leads to significant positive therapeutic outcomes in one group of patients who showed totally distinct patterns of alternation to different groups of lymphocytes.
