H Hosseinzadeh, Me Shooshtari,
Volume 12, Issue 4 (2-1999)
Abstract
There are several reports that adenosine and carbamazepine have
pharmacodynamic interaction. I n this study the antinociceptive interaction o f these
two agents was evaluated in mice by the hot plate test. Agents were injected
intraperitoneally.
0.2 and 0.4 mg/kg doses of R-phenylisopropyladenosine (R-PIA) substantially
showed antinociceptive effects. Carbamazepine had antinociceptive actions except
at a dose of 0.8 mg/kg. Theophylline (12.5 mg/kg), as a non-selective antagonist of
adenosine receptors, showed a nociceptive effect. Dipyridamole, an uptake blocker
of adenosine, had no antinociceptive effect even with a dosage of 90 mg!k:g.
Theophylline did not decrease the antinociceptive effect of carbamazepine, while
dipyridamole increased the antinociceptive effect of carbamazepine 30 min utes after
administration. Carbamazepine (8 mg/kg) inhibited the antinociceptive effect of RPIA.
This study supports the possibility that the interaction between adenosine and
carbamazepine may be related to their actions at adenosine receptor sites in the brain.
