D Al-Saadi, We Sneader,
Volume 7, Issue 3 (11-1993)
Abstract
Following our previous investigations on certain new aminoalkyl aryl ethers,
which showed promising and outstanding local anaesthetic properties, the local
anaesthetic activity and duration of action of a further selection of four novel
derivatives of the above-mentioned series, used as hydrochloride salts, have been
determined by the ill vivo rat sciatic nerve test. These are: N,N-dimethyl-2-(2,6-ditert-
butylphenoxy)ethylamine N, N-dimethyl-2-(4-butoxyphenoxy) ethylamine
N, N-dimethyl-2-(2,6-di-sec-butylphenoxy)ethylamine and N,N-diethyl-2-(4-secbutylphenoxy)
ethylamine. The tests have been performed by a double blind, controlled
trial (at the later stage) and in two stages. Bupivacaine hydrochloride has been
employed as the standard and normal saline as the control. The complete loss of
motor function of the injected limb of the animal is considered as a positive response,
which is assessed by observing the animal gait and ability to climb up a sloping wire
mesh. The test compounds have exhibited shorter duration of motor paralysis than
that of the standard and comparable rates of both onset of action, and recovery time
from full analgesia. They also have shown neither apparent systemic nor local side
effects such as edema, swelling, induration, ulceration, necrosis, or irritation.
