Volume 14, Issue 2 (8-2000)                   Med J Islam Repub Iran 2000 | Back to browse issues page


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REZAYAT M, GHAZI-KHANSARI M, MOUSTAFAVI-MEHR B, ZARRINDAST M. EFFECTS OF CHOLECYSTOKININ RECEPTOR ANTAGONISTS ON MORPHINE- AND COCAINEINDUCED HYPOTHERMIA. Med J Islam Repub Iran. 2000; 14 (2) :151-154
URL: http://mjiri.iums.ac.ir/article-1-881-en.html

From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences,
Abstract:   (1878 Views)
The effects of cholecystokinin (CCK) receptor antagonists on hypothermia induced by cocaine or morphine have been studied in mice. In the present work, subcutaneous (SC) injection of cocaine (50-150 mg/kg) or morphine (125-500 mg/kg) induced hypothermia in mice. Administration of CCKA receptor antagonist MK-329 (0.5-1.5 mg/kg), CCKB receptor antagonist L-365, 260 (0.5-1.5 mgl kg) and CCK receptor antagonist proglumide (15-45 mg/kg) 60 min. prior to cocaine injection reduced hypothermia induced by cocaine. MK-329 or proglumide also reduced the morphine response. Single administration of MK-329 and L- 365,260 to mice decreased mice core body temperature. It is concluded that the hypothermic effect of cocaine and morphine may be mediated through CCKA and CCKB receptor mechanism(s).
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