Volume 12, Issue 3 (11-1998)                   Med J Islam Repub Iran 1998 | Back to browse issues page

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MORADMAND S, NIAKAN M, FOULADKOU F, SHAFIEE A. A CLINICAL TRIAL TO EVALUATE THE EFFICACY OF FLUVASTATIN AND LOVASTATIN IN COMPARISON WI TH PLACEBO IN HYPERCHOLESTEROLEMIC PATIENTS. Med J Islam Repub Iran 1998; 12 (3) :229-233
URL: http://mjiri.iums.ac.ir/article-1-1000-en.html
A CLINICAL TRIAL TO EVALUATE THE EFFICACY OF FLUVASTATIN AND LOVASTATIN IN COMPARISON WI TH PLACEBO IN HYPERCHOLESTEROLEMIC PATIENTS
S MORADMAND , MR NIAKAN , F FOULADKOU , A SHAFIEE
From the Department of Pharmacy and Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Abstract:   (4353 Views)
In this study, the effect of lovastatin and fluvastatin was compared with placebo in patients with high levels of total cholesterol and low density lipoprotein cholesterol (LDL-C) on the plasma lipid profile. In a prospective single blind clinical trial with convenient sampling, 120 hypercholesterolemic men and women with Tcholesterol ≥220 mg/dL, LDL-C ≥ 160 mg/dL, and triglyceride ≤ 350 mg/dL were selected and divided into 3 groups randomly. The fust group took lovastatin, 20 mg daily, the second group fluvastatin, 40 mg daily, and the third group took a placebo, all for 12 weeks. Compared with placebo, drug therapy of hypercholesterolemia with either lovastatin or fluvastatin decreased total cholesterol and LDL-C levels significantly but had no effect on high density lipoprotein and triglyceride values. Decrease of total cholesterol and LD L-C levels by both drugs are similar after the first 6 weeks but lovastatin was more effective after the second 6 week period.
Keywords: Fluvastatin, Lovastatin, Hypercholesterolemia
Full-Text [PDF 404 kb]   (1393 Downloads)    
Type of Study: Original Research | Subject: Pharmacology
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