Volume 26, Issue 3 (8-2012)                   Med J Islam Repub Iran 2012 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Nasiri S, Soroush A, Hashemi A P, Hedayat A, Donboli K, Mehrkhani F. Parathyroid adenoma Localization. Med J Islam Repub Iran 2012; 26 (3) :103-109
URL: http://mjiri.iums.ac.ir/article-1-1052-en.html
Parathyroid adenoma Localization
Shirzad Nasiri , Ahmadreza Soroush , Amir Pejman Hashemi , Anushiravan Hedayat , Kianoush Donboli , Farhad Mehrkhani
Tehran University of Medical Sciences, Tehran, Iran. , nasiri@razi.tums.ac.ir
Abstract:   (5785 Views)
 Background: Bilateral neck exploration is the gold standard for parathyroid adenoma localization in primary hyperparathyroidism. But surgeons do not have adequate experience for accurate surgical exploration and new methods are developed for surgery like unilateral exploration and minimally invasive surgery, thus, preoperative localization could reduces time and stress in surgical performance.

 

Method: 80 patients with documented primary hyperparathyroidism and with raised serum calcium and parathyroid hormone (PTH) were selected. The results of ultrasonographic localization for each patient were compared with findings of surgery and 99m technetium sestamibi scintigraphy. Also variables such as preoperative serum calcium, PTH level and adenoma weight were compared between patients who had localized and nonlocalized adenoma with ultrasonography or Sestamibi scan. The data was compared with student’s t-test.

 Results: In a prospective diagnostic tests’ accuracy, 80 patients with primary hyperparathyroidism were enrolled. Ultrasonography images detected enlarged parathyroid glands in 61 of 80 patients (76.3%) with sensitivity of 83.5% and positive predictive value (PPV) of 89.7%. Sestamibi scintigraphy detected adenoma in 63 patients (78.8%) with sensitivity of 85% and PPV of 91.3%. There was no significant deference between ultrasonography and scintigraphy in localization of adenomas. Both ultrasonography and scintigraphy used for determining localization, and they located 73 adenomas (91.3%) with sensitivity of 97.3% and PPV of 93.5%.

 

Conclusion: Ultrasonography as an accurate method for localization of enlarged parathyroid glands in primary hyperparathyroidism, is comparable in overall utility with sestamibi scintigraphy. This study suggests a strategy for initial testing with one method, followed by the alternate imaging test if the first test happen to be negative.

 
Keywords: Primary hyperparathyroidism, Scintigraphy, Ultrasonography, Localization.
Full-Text [PDF 220 kb]   (1865 Downloads)    
Type of Study: Original Research | Subject: Surgery
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.