Volume 11, Issue 4 (2-1998)                   Med J Islam Repub Iran 1998 | Back to browse issues page

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KHAJEHDEHI P, GHALAMBOR M. IMPROVING ERYTHROPOIESIS BY HEMODIALYSIS: RELATIONSHIP WITH A DEQUACY, FREQUENCY A ND DURATION OF DIALYSIS. Med J Islam Repub Iran 1998; 11 (4) :299-302
URL: http://mjiri.iums.ac.ir/article-1-1070-en.html
IMPROVING ERYTHROPOIESIS BY HEMODIALYSIS: RELATIONSHIP WITH A DEQUACY, FREQUENCY A ND DURATION OF DIALYSIS
P KHAJEHDEHI , MA GHALAMBOR
From the Division of Nephrology, Department of Internal Medicine, School of Medicine,
Abstract:   (5062 Views)
Serum erythropoietin (EPO) concentration was measured by an enzyme-linked immunosorbent assay (ELISA) in 31 cases of chronic renal failure (CRF), including 20 hemodialysis (HD) patients, and compared with that of 31 healthy normal controls. Each patient served as a self-control comparing his or her pretreatment level with post-treatment values. There was a significant negative correlation between serum EPO and serum iron ( SI) concentration in HD patients (p<0.05) the correlation was more prominent after three months of hemodialysis (p<0.00l). The mean hemoglobin (Hb) concentration was significantly higher in patients who underwent HD more than once per week as compared with those who received HD once a week (p<0.00 1). In addition, patients on three months of HD had a higher Hb level as compared to those who had received HD for one month (p<0.001). Moreover, there was also a significant negative correlation between serum EPO concentration and dialysis adequacy (p<0.05), indicating that the erythropoietin-hematocrit feedback inhibition mechanism had improved due to general improvement of the patients' metabolism and possible removal of dialyzable toxins.
Keywords: Erythropoietin, anemia, chronic renal failure, hemodialysis.
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Type of Study: Original Research | Subject: Internal Medicine
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