Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Tue, Jul 16, 2024
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Volume 10, Issue 4 (2-1997)
Med J Islam Repub Iran 1997 |
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SEMNANIAN S, HAJISAYAH S, ZARRINDAST M. INVOLVEMENT OF SUPRASPINAL ALPHAADRENERGIC RECEPTORS IN TONIC PAIN. Med J Islam Repub Iran 1997; 10 (4) :279-284
URL: http://mjiri.iums.ac.ir/article-1-1154-en.html
URL: http://mjiri.iums.ac.ir/article-1-1154-en.html
From the Department of Physiology, Shaheed Beheshti University of Medical Sciences
Abstract: (3967 Views)
The involvement of supraspinal alpha-adrenergic receptors in tonic pain was
assessed in formalin-induced pain in rats. The alpha2 adrenoceptor agonist
clonidine, along with yohimbine and prazosin, α2 and α1 receptor antagonists,
were introduced intracerebroventrically (icv) and/or systemically in different
doses. The data show that 1) clonidine exerts an alpha adrenergic analgesic effect,
in addition to its known alpha2 role in this kind of pain, 2) icv yohimbine did not
change the rat's nociception, and 3) icy prazocin also failed to alleviate the animal's
nociception although both the latter drugs show analgesic activity in the formalin
test when injected systemically. It can be concluded that α1 receptors contribute
significantly to adrenergic analgesia in the formalin test in supraspinal structures,
by undefined nature and site(s).
Type of Study: Original Research: Basic Science in Medicine |
Subject:
Physiology
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