Volume 10, Issue 3 (11-1996)                   Med J Islam Repub Iran 1996 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BOSKABADY M, SNASHALL P. SHORT TERM VARIATION OF ATROPINE BLOCKADE IN THE TRACHEOBRONCHIAL TREE OF ASTHMATIC SUBJECTS. Med J Islam Repub Iran 1996; 10 (3) :183-189
URL: http://mjiri.iums.ac.ir/article-1-1170-en.html
SHORT TERM VARIATION OF ATROPINE BLOCKADE IN THE TRACHEOBRONCHIAL TREE OF ASTHMATIC SUBJECTS
MH BOSKABADY , PD SNASHALL
From the Department of Physiology. Ghaem Medical Center. Mashhad University of Medical Sciences. Mashhad. Iran
Abstract:   (4501 Views)
In asthmatic subjects there is a pronounced diurnal variation in bronchial responsiveness. If this phenomenon is due to variation in factors that control drug delivery, then it should be paralleled by a similar variation in competitive antagonist blockade. In order to study this possibility, we performed the methacholine challenge test and after 45 minutes, administered atropine by inhalation. Methacholine rechallenge was performed 25 minutes after premedication with atropine. Bronchial responsiveness to methacholine(pB3s) and atropine blockade was then measured. Eight normal subjects and 9 asthmatic patients were tested on two separate occasions, one in the morning at 08:00 hours and the other in the evening at 18:00 hours with at least 48 hours gap between them. In normal subjects there was no significant difference between morning and evening concerning airway caliber, bronchial responsiveness to methacholine and atropine blockade. In asthmatic patients there was a significant difference between morning and evening in bronchial responsiveness to methacholine (P<0.001) and atropine blockade (P<0.001), although there was no significant difference in airway caliber. The possible explanation for' enhanced atropine blockade as well as methacholine responsiveness in asthmatic subjects in the morning is increased bronchial and tissue permeability due to worsening bronchial inflammation in the early morning leading to increased drug delivery to active sites in the airways.
Keywords: Short term variation, atropine blockade, asthma.
Full-Text [PDF 999 kb]   (1539 Downloads)    
Type of Study: Original Research | Subject: Physiology
Add your comments about this article : Your username or Email:
CAPTCHA
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.