Volume 10, Issue 2 (8-1996)                   Med J Islam Repub Iran 1996 | Back to browse issues page

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HAKOPIAN V P, KANAYAN A S, MELKONIAN K V. THE MORPHO-FUNCTIONAL STATE OF THE BRAIN UNDER CONDITIONS OF HYPOKINESIA AND ITS POSSIBLE PHARMACOLOGICAL CORRECTION BY GABA-ERGIC SUBSTANCES. Med J Islam Repub Iran 1996; 10 (2) :153-158
URL: http://mjiri.iums.ac.ir/article-1-1204-en.html
THE MORPHO-FUNCTIONAL STATE OF THE BRAIN UNDER CONDITIONS OF HYPOKINESIA AND ITS POSSIBLE PHARMACOLOGICAL CORRECTION BY GABA-ERGIC SUBSTANCES
VILEN P. HAKOPIAN , ALEXANDER S. KANAYAN , KARINE V. MELKONIAN
From the Department of Pharmacology, State Medical Institute, Yerevan, Republic of Armenia.
Abstract:   (3296 Views)
In this paper it has been shown that deterioration of the brain cortex capillary system and negative dynamics of cerebral tissue morphology occur under conditions of hypo kinesia. Simultaneously, gamma-aminobutyric acid (GABA) and piracetam have been shown to favor the development of vasodilation and prevent further worsening of the cerebral blood supply. During the experiment, it was also established that among the substances investigated, the specific antagonist of GABA-receptors-bicuculline-displays the strongest cerebroprotective effect in early hypokinesia.
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Type of Study: Original Research: Basic Science in Medicine | Subject: Pharmacology
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