Volume 9, Issue 3 (10-1995)                   Med J Islam Repub Iran 1995 | Back to browse issues page

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GHADERI A A, AGAHI M, AMIRGHOFRAN Z, ARDEHALI S. DETERMINATION OF A SHARED EPITOPE ON CELLS FROM ACUTE MYELOGENIC LEUKEMIA (AML) AND T-ACUTE LYMPHOBLASTIC LEUKEMIA ( T-ALL). Med J Islam Repub Iran 1995; 9 (3) :253-255
URL: http://mjiri.iums.ac.ir/article-1-1328-en.html
DETERMINATION OF A SHARED EPITOPE ON CELLS FROM ACUTE MYELOGENIC LEUKEMIA (AML) AND T-ACUTE LYMPHOBLASTIC LEUKEMIA ( T-ALL)
ABBAS A. GHADERI , MH AGAHI , Z AMIRGHOFRAN , S ARDEHALI
From the Dept. of Microbiology and Immunology, Medical School, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Abstract:   (4192 Views)
Two IgM monoclonal antibodies (MAb) with strong reactivity for granulocytes and to a lesser extent for lurkat cell lines were established by immunizing BALBI c mice with a histiocytic cell line (UY37). These two MAbs (designated as 6C9 and 4C4) reacted with blast cells of T-acute lymphoblastic leukemia (T-ALL) and acute myelogenous leukemia (AML) patients as well as leukemic cells from patients known as unclassified leukemia (UL). According to their pattern of reactivity, it is most probable that these two IgM MAbs react with some highly glycosylated membrane determinants such as 3-fucosyl-N-acetyllactosamine (3- FAL) which are exclusively expressed on some subsets of granulocytes and AML cells.
Keywords: Granulocyte, Leukemia, CDI5
Full-Text [PDF 259 kb]   (1513 Downloads)    
Type of Study: Original Research: Basic Science in Medicine | Subject: Microbiology and Anatomy
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