Volume 9, Issue 2 (8-1995)                   Med J Islam Repub Iran 1995 | Back to browse issues page

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RAFI A, BABAN B. EVALUATION OF DIRECT MICROSCOPY, CULTURE, AND POLYMERASE CHAIN REACTION FOR THE DIAGNOSIS OF TUBERCULOUS MENINGITIS. Med J Islam Repub Iran 1995; 9 (2) :107-110
URL: http://mjiri.iums.ac.ir/article-1-1333-en.html
EVALUATION OF DIRECT MICROSCOPY, CULTURE, AND POLYMERASE CHAIN REACTION FOR THE DIAGNOSIS OF TUBERCULOUS MENINGITIS
ABDOLNASSER RAFI , BABAK BABAN
From the Department of Medical Microbiology, University College London Medical School, University of London, London, England.
Abstract:   (4095 Views)
In view of the importance of early diagnosis of tuberculous meningitis (TBM), the efficiency of the polymerase chain reaction (PCR), one of the most reliable and sensitive DNA-based assays, was compared with conventional methods (acid-fast microscopy and culture) for the detection of M. tuberculosis in cerebrospinal fluid (CSF) specimens from patients suspected of TBM. Of the 29 CSF specimens from highly probable TBM patients (based on clinical features), 25 were positive by PCR (86.2%), was acid-fast microscopy (AFM) positive (3.4%), positive (17.2%). No positive results were found by AFM, culture or PCR in the nontuberculous control group. The results of this study indicate that application of PCR should be extremely useful for the diagnosis of TBM.
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Type of Study: Original Research | Subject: Microbiology and Anatomy
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