Volume 9, Issue 2 (8-1995)                   Med J Islam Repub Iran 1995 | Back to browse issues page

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NOBAKHT M, TAKl M, REZAZADEH M, SHARlAT TORBAGHAN S. STAG ES OF DEVELOPMENT OF RENAL GLOMERULI IN THE NEWBORN RAT KIDNEY. Med J Islam Repub Iran 1995; 9 (2) :147-152
URL: http://mjiri.iums.ac.ir/article-1-1341-en.html
STAG ES OF DEVELOPMENT OF RENAL GLOMERULI IN THE NEWBORN RAT KIDNEY
M NOBAKHT , MT TAKl , M REZAZADEH , S SHARlAT TORBAGHAN
From the Department of Anatomy, Tarbiat Modarres University, and the Cancer Institute of Imam Khomeini Hospital, Tehran, Islamic Republic of Iran.
Abstract:   (4423 Views)
Glomerular development of the kidney was studied in newborn rats by electron microscopy. Four different stages of glomerular development were defined: vesicle fonnation, S-shaped body stage, capillary loop fonnation, and glomerular maturation. In the fust stage, the mesenchymal cells form a spheroid mass. This is followed by the S-shaped body stage in which clefts appear in the mass. Afterwards, capillary loop formation, junctional migration, podocyte differentiation, and interdigitation of epithelial processes occur. Finally, the cytoplasm of endothelial cells becomes thinner. The urinary space is visible in this stage. The fusion of epithelial and endothelial basement membranes results in fonnation of the layers of the GBM. The increase in the number of podocyte processes and endothelial cell fenestrations are important events in the maturation phase.
Keywords: Development, Glomerular stages, Basement membrane
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Type of Study: Original Research: Basic Science in Medicine | Subject: Microbiology and Anatomy
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