From the Imam Hosein University, of Medical Sciences, Tehran, Islamic Republic of Iran.
Abstract: (3286 Views)
Clomiphene citrate (CC) has an adverse effect on the quality and quantity
of cervical mucus (CM). Poor cervical mucus has been reported in 15%
of CC-treated women. CC exhibits estrogen agonist and antagonist activities.
Antiestrogenic activity affecting the endocervical glands is theorized to
cause a decrease in cervical mucus quality and quantity. An experimental
study was performed to assess if there is any relation between poor CM and
the level of estrogen in those to whom the drug is administered. We used CC
on 50 subjects and evaluated CM and measured serum E2 levels simultaneously.
We concluded that there is no relation between the level of estrogen
and the quality or quantity of CM in these patients.