Volume 8, Issue 4 (2-1995)                   Med J Islam Repub Iran 1995 | Back to browse issues page

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BOOJAR M, RABBANI A. THE EFFECT OF THEOPHYLLINE ON THE KINETICS OF cAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT, cAMP, PROTEIN KINASE INHIBITOR AND THEIR RELATIONSHIP IN LUNG TISSUE. Med J Islam Repub Iran 1995; 8 (4) :249-253
URL: http://mjiri.iums.ac.ir/article-1-1365-en.html
THE EFFECT OF THEOPHYLLINE ON THE KINETICS OF cAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT, cAMP, PROTEIN KINASE INHIBITOR AND THEIR RELATIONSHIP IN LUNG TISSUE
MASSOUD BOOJAR , AZRA RABBANI
From the Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Islamic Republic of Iran.
Abstract:   (3750 Views)
We have investigated the effect of theophylline on the kinetics of the catalytic subunit of protein kinase and related factors in lung tissue. The results show that the point of highest concentration of the C subunit of protein kinase which is active in casein phosphorylation is at 3h of incubation time, but in the presence of 100 Ilg/ InL and 10µg/mL theophylline, this is shifted to I.S and 2.S hrs, respectively. Also the maximum concentration of cAMP for the control is at 2.S h of incubation time, butin the treated samples shifts to 2.15 and LIS hrs, respectively. Inhibitor protein content also changes considerably in the presence of 10µg/mL theophylline. The results suggest an effect of theophylline on the function of cAMP-dependent protein kinase.
Keywords: Theophylline, cAMP, catalytic; subunit, inhibitor protein, protein kinase
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Type of Study: Original Research: Basic Science in Medicine | Subject: Biological Sciences
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